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E-book

Title Drug Efficacy, Safety, and Biologics Discovery : Emerging Technologies and Tools / edited by Sean Ekins, Jinghai J. Xu
Published Hoboken, N.J. : John Wiley & Sons, ©2009

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Description 1 online resource (xvi, 408 pages, 16 unnumbered pages of plates) : illustrations (some color)
Series Wiley series on technologies for the pharmaceutical industry
Wiley series on technologies for the pharmaceutical industry.
Contents Focus on the fundamentals : toward better therapeutic index prediction / Jinghai J. Xu and Li J. Yu -- High-throughput protein-based technologies and computational models for drug development, efficacy, and toxicity / Leonidas G. Alexopoulos, Julio Saez Rodriguez, and Christopher W. Espelin -- Cellular systems biology applied to preclinical safety testing : a case study of CellCiphr profiling / Lawrence Vernetti [and others] -- Systems pharmacology, biomarkers, and biomolecular networks / Aram S. Adourian [and others] -- Zebrafish models for human diseases and drug discovery / Hanbing Zhong, Ning-Ai Liu, and Shuo Lin -- Toxicity pathways and models : mining for potential side effects / Sean Ekins and Josef Scheiber -- Computational systems biology modeling of dosimetry and cellular response pathways / Qiang Zhang [and others]
Stem cell technology for embryotoxicity, cardiotoxicity, and hepatotoxicity evaluation / Julio C. Davila [and others] -- Telemetry technology for preclinical drug discovery and development / Yi Yang -- Nanotechnology to improve oral drug delivery / Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji -- Functional glycomics and the future of glycomic drugs / Ram Sasisekharan and Karthik Viswanathan -- Modeling efficacy and safety of engineered biologics / Jeffrey R. Chabot and Bruce Gomes -- Regulation of gene expression by small, non-coding RNAS : practical applications / Roman Herrara and Eric Tien -- Future perspectives of biological engineering in pharmaceutical research : the paradigm of modeling, mining, manipulation, and measurements / Jinghai J. Xu [and others]
Summary This book covers key emerging technologies - detailed under About the Topic - in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Drug development -- Technological innovations
Pharmaceutical technology.
Biological products.
Drugs -- Design.
Drugs -- Side effects.
Drug Evaluation -- trends
Biological Products
Drug Design
Drug-Related Side Effects and Adverse Reactions
Technology, Pharmaceutical -- trends
Technology, Pharmaceutical
Biological Factors
Biological products.
Pharmaceutical technology.
Veiligheid.
Bijwerkingen.
Nanotechnologie.
Biofarmacie.
Glycoproteïnen.
Koolhydraten.
Toxicologie.
Geneeskrachtige werking.
Form Electronic book
Author Ekins, Sean.
Xu, Jinghai J.
LC no. 2008036264
ISBN 9780470431801
0470431806
9780470431818
0470431814