| Description |
1 online resource (276 pages) |
| Contents |
Introduction -- Addison and his disease -- Introducing Dr. Kendall -- Life after the thyroid -- Introducing Dr. Hench -- Nice guys, saints, eccentrics, and geniuses -- 1929 and the decision to hunt for cortisone -- Another Kendall false start, another great announcement -- Kendall strikes out again -- Kendall presses on -- Score: Szent-Györgyi-1; Kendall-0 -- Transitions and travels -- War looms -- Hench meets Kendall -- World War II and military steroid research -- Plants, politicians, and more pessimism -- Good-bye Marker, hello Sarett -- Hench returns to Mayo -- Push on? Give up? -- The decision to test compound E on rheumatoid arthritis -- The amazing Mrs. G. -- A promising start -- The bad and the ugly -- Progress and setbacks -- Convincing the skeptics -- Announcement -- The prize -- Stockholm -- Aftermath -- Twilight -- The end of the show -- Notes |
| Summary |
"In 1948, when "Mrs. G.," hospitalized with debilitating rheumatoid arthritis, became the first person to receive a mysterious new compound -- cortisone -- her physicians were awestruck by her transformation from enervated to energized. After eighteen years of biochemical research, the most intensively hunted biological agent of all time had finally been isolated, identified, synthesized, and put to the test. And it worked. But the discovery of a long-sought "magic bullet" came at an unanticipated cost in the form of strange side effects. This fascinating history recounts the discovery of cortisone and pulls the curtain back on the peculiar cast of characters responsible for its advent, including two enigmatic scientists, Edward Kendall and Philip Hench, who went on to receive the Nobel Prize. The book also explores the key role the Mayo Clinic played in fostering cortisone's development, and looks at drugs that owe their heritage to the so-called "King of Steroids.""--Project Muse |
| Bibliography |
Includes bibliographical references |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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English |
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Print version record |
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digitized 2011 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Kendall, Edward C. (Edward Calvin), 1886-1972.
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Hench, Philip S. (Philip Showalter), 1896-1965.
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| SUBJECT |
Hench, Philip S (Philip Showalter), 1896-1965 |
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Kendall, Edward C (Edward Calvin), 1886-1972 |
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Hench, Philip S. (Philip Showalter), 1896-1965 fast |
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Kendall, Edward C. (Edward Calvin), 1886-1972 fast |
| Subject |
Mayo Clinic.
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| SUBJECT |
Mayo Clinic |
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Mayo Clinic fast |
| Subject |
Cortisone -- History
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Drug development.
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Cortisone -- history
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Clinical Trials as Topic -- history
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Cortisone -- therapeutic use
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Drug Discovery -- history
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Drug Evaluation -- history
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History, 20th Century
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MEDICAL -- History.
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Cortisone
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Drug development
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| SUBJECT |
United States |
| Genre/Form |
History
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| Form |
Electronic book
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| LC no. |
2011031277 |
| ISBN |
9781609173265 |
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1609173260 |
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9781628951257 |
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1628951257 |
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9781628961256 |
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1628961252 |
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