| Description |
1 online resource (xiii, 444 pages) : illustrations (some color |
| Series |
Methods in molecular biology, 1064-3745 ; 356 |
|
Methods in molecular biology (Clifton, N.J.) ; v. 356
|
| Contents |
Past, present, and future of high content screening and the field of cellomics / D.L. Taylor -- A pharmaceutical company user's perspective on the potential of high content screening in drug discovery / A.F. Hoffman and R.J. Garippa -- Linking microscopy and high content screening in large-scale biomedical research / J.G. Evans and P. Matsudaira -- Requirements, features, and performance of high content screening platforms / A.H. Gough and P.A. Johnston -- Characteristics and value of directed algorithms in high content screening / R.N. Ghosh, O. Lapets and J.R. Haskins -- Characteristics and value of machine learning for imaging in high content screening / J.A. Klenk -- Tools for quantitative and validated measurements of cells / A.L. Plant [and others] -- Automated cell plating and sample treatments for fixed cells in high content assays / G.R. Richards [and others] -- Differentiating primary human cells in rapid-throughput discovery applications / D.R. Marshak and D.E. Greenwalt -- Use of the CellCard System for analyzing multiple cell types in parallel / O. Beske, D. Bassoni and S. Goldbard -- Reagents to measure and manipulate cell functions / K.A. Giuliano, D.L. Taylor and A.S. Waggoner -- Fluorescent proteins and engineered cell lines / N. Thomas -- Optimizing the integration of immunoreagents and fluorescent probes for multiplexed high content screening assays / K.A. Giuliano -- The HaloTag: a novel technology for cell imaging and protein analysis / G.V. Los and K. Wood -- Protein labeling with FlAsH and ReAsH / T. Machleidt, M. Robers and G.T. Hanson -- Exploiting network biology to improve drug discovery / M.L. MacDonald and J.K. Westwick -- Physiological indicators of cell function / M.J. Ignatius and J.T. Hung -- The use of siRNA to validate immunofluorescence studies / K.G. Moore, W. Speckmann and R.P. Herzig -- Caged substrates applied to high content screening: an introduction with an eye to the future / P.G. Conrad, 2nd, R.V. Chavli and R.S. Givens -- Overview of informatics for high content screening / R.T. Dunlay, W.J. Czekalski and M.A. Collins -- Large-scale data management for high content screening / L.S. Garfinkel -- An integrated biomedical knowledge extraction and analysis platform: using federated search and document clustering technology / D.P. Taylor -- Visualization of high content screening data / M.J. Anstett -- Pathway mapping tools for analysis of high content data / S. Ekins [and others] -- Systems biology in cancer research: genomics to cellomics / J.L. Stilwell [and others] -- Target validation in drug discovery / R.A. Blake -- High content screening as a screening tool in drug discovery / A. Nichols -- Discovery of protein kinase phosphatase inhibitors / A. Vogt and J.S. Lazo -- High content translocation assays for pathway profiling / F. Loechel [and others] -- In vitro cytotoxicity assessment / P. O'Brien and J.R. Haskins -- Neurite outgrowth in retinal ganglion cell culture / J.B. Kerrison and D.J. Zack |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on print version record |
| Subject |
Biological systems -- Research -- Methodology.
|
|
Computational biology.
|
|
Drug development -- Computer simulation.
|
|
Systems Biology -- methods.
|
|
Drug Design.
|
|
Image Processing, Computer-Assisted -- methods.
|
| Form |
Electronic book
|
| Author |
Taylor, D. Lansing.
|
|
Haskins, Jeffrey R.
|
|
Giuliano, Kenneth A.
|
| ISBN |
9781597452175 (electronic bk.) |
|
1597452173 electronic bk |
|
