A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Down syndrome -- Patients -- Education -- Spain : Education, disability and inclusion : a family struggle against an excluding school / Ignacio Calderón-Almendros, University of Malaga, Spain and Sabina Habegger-Lardoeyt, CIMAS Observatory, Spain
Down syndrome -- Patients -- New York (State) -- New York : Forget me not / Alana and Videocamp present ; in associatiion with Flow Impact ; a Rota6 Films production ; a Maria Farinha Filmes production ; a film by Olivier Bernier
Down syndrome -- Patients -- Social conditions : A different kind of day / Bord Scannán na hÉireann / the Irish Film Board in association with Mermaid Productions presents ; producer/music composer, Kieran Kennedy ; writer/director, Maria Doyle Kennedy
Down syndrome -- Physiological aspects. : Down's syndrome : psychological, psychobiological, and socio-educational perspectives / edited by Jean A. Rondal ... [and others]