| Description |
1 online resource (390 pages) |
| Contents |
Front Cover; The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae; Copyright; Dedication ; Contents; Preface; Acknowledgments; Chapter I: History of Immunology Research; Before 1945: The Early Days; 1945-1960: Immunology Reawakens; 1960-Today: Pure Immunology; Summary; Pathogenic Effector Mechanisms of Chronic Inflammatory Systemic Diseases; Autoantibody, Immune Complex, and Complement; B Cells and Plasma Cells; T Cells; MHC and Immunogenetics; Monocytes and Macrophages; Dendritic Cells; NK Cells; Neutrophils; Apoptosis |
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Adhesion and Costimulatory Molecules, Vascular Transmigration, and ChemokinesPattern Recognition Receptors; The Local Cellular Support System of Inflammation; Fibroblasts and Astrocytes; Stromal Cells of the Bone Marrow; Endothelial Cells, Mesangial Cells, and Neovascularization; Epithelial Cells; Keratinocytes; Oligodendrocytes; Adipocytes; Myocytes; Eosinophils, Basophils, and Mast Cells; Signaling Pathways: Genome-Wide Association Studies; The Trigger of Chronic Inflammatory Systemic Diseases; The Timescale; The Asymptomatic Phase of Chronic Inflammatory Systemic Diseases |
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The Symptomatic Phase of Chronic Inflammatory Systemic DiseasesThe Plasticity Phase of Chronic Inflammatory Systemic Diseases in Early Life; Summary; Chapter II: Pathogenesis and Neuroendocrine Immunology; Historical Remarks; Physiological Basis; Receptors for Hormones and Neurotransmitters on Immune Cells; Dual Roles of Hormones and Neurotransmitters/Neuropeptides; Availability of Hormones and Neurotransmitters/Neuropeptides in the Tissue; Switching on the Systemic Response Systems; Differential Activation and Inhibition of Response Systems |
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Influence of Hormones and Neurotransmitters/Neuropeptides on Immune FunctionEndocrine Immune Relations in Chronic Inflammatory Systemic Diseases; Inadequate Secretion of Cortisol Relative to Inflammation; The Link Between TNF and Hormone Axes; The Possible Role of Adrenal Mitochondria in the Relative Decrease of Adrenal Steroid Secretion During Inflammation; The Women-to-Men Preponderance in Rheumatic Diseases: The Role of Sex Hormones; Loss of Adrenal and Gonadal Androgens; Increased Conversion of Androgens to Estrogens; DHEA and the Risk of Developing a Chronic Inflammatory Systemic Disease |
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CRH in Local InflammationElevated Levels of Melatonin and Prolactin; Vitamin D Hypovitaminosis; The Hypothalamic-Pituitary-Thyroid Gland Axis; Insulin and Insulin-Like Growth Factor 1 are Proinflammatory; Insulin Resistance is a Proinflammatory Signal; Growth Hormone: Dual Roles in Adults and Children; Angiotensin II is Proinflammatory; Adipokines are Proinflammatory; Hormonal Influence on T Helper Type 17 Cells and T Regulatory Cells; Neuroimmunology in Chronic Inflammatory Systemic Diseases; Introduction ; Acute Inflammation (Phase 1: The First 12 h) |
| Summary |
Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Inflammation -- Immunological aspects.
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Aging -- Diseases
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Inflammation.
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Autoimmune diseases.
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Chronic diseases.
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Endocrine glands -- Diseases.
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Neuroendocrinology.
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Neuroimmunology.
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Autoimmune Diseases
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Chronic Disease
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Endocrine System Diseases
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Inflammation -- physiopathology
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Neuroendocrinology
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Neuroimmunomodulation
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Inflammation
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Neuroimmunology.
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Neuroendocrinology.
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Endocrine glands -- Diseases.
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Chronic diseases.
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Autoimmune diseases.
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Inflammation.
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Inflammation -- Immunological aspects.
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| Form |
Electronic book
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| ISBN |
9780128033227 |
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0128033223 |
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