| Description |
1 online resource (377 pages) |
| Contents |
Cover; Title Page; Copyright; Contents; List of Contributors; Foreword; Preface; Chapter 1 Endoderm Development: From Progenitors to Organ Buds; Introduction; Emergence of the Progenitor Population; Allocation of the Endoderm Progenitors; Regionalization of Cell Fates; Establishment and Maintenance of the Epithelial Endoderm Layer; Morphogenesis of the Embryonic Gut; Signaling Activities Controlling Endoderm Formation; Regionalization of the Embryonic Gut; Patterning in the Anterior-Posterior Axis; Patterning in the Dorsal-Ventral Dimension; Laterality of the Gut Tube |
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Formation of the Organ PrimordiaInitiation of Organ Budding; Organ-Specific Developmental Features; Relevance of the Embryology of the Gut to Clinical Conditions; Acknowledgments; References; Chapter 2 Genetic and Cellular Mechanisms Regulating Esophageal Development; Introduction; Initial Specification of the Esophagus from the Anterior Foregut; Evolving Models for Anterior Foregut Separation; Dorsal-Ventral Patterning of the Transcription Factors Sox2 and Nkx2.1 in the Anterior Foregut; Signaling Pathways Regulating the Separation of the Esophagus from the Early Foregut |
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Retinoic Acid (RA) SignalingMorphogenesis of the Esophagus After Separation from the Foregut Endoderm; Transcription Factors and Signaling Pathways That Regulate the Transformation of Esophageal Epithelium; Development of Esophageal Muscle Cells; Future Questions; Acknowledgments; References; Chapter 3 Congenital and Acquired Diseases of the Esophagus; Introduction; Esophageal atresia (EA); Genes Implicated in EA-TEF and Esophageal Development; Prenatal Diagnosis of TA-TEF; Clinical Presentation of TA-TEF; Treatment of EA-TEF; Prognosis of EA-TEF; Barrett's Esophagus (BE) |
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Pathophysiology of BEClinical Presentation of BE; Diagnosis of BE; Screening and Surveillance for BE; Treatment of BE; Biomarkers to Supplement Histology; Achalasia; Pathophysiology; Etiology; Clinical Presentation; Diagnosis; Treatment; Future Questions; References; Chapter 4 Basic Science of Stomach Development; Introduction; Foregut Specification and Regionalization; Stomach Specification and Proximal-Distal Patterning; Developmental Signaling in Stomach Growth, Morphogenesis, and the Radial Axis; Stomach Differentiation; Stomach Stem Cells; Clonality of Gastric Epithelial Glands |
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Gastric Homeostasis as an Extension of Stomach DevelopmentFuture Questions; References; Chapter 5 Congenital and Acquired Diseases of the Stomach; Introduction; Congenital Clinical Disorders; Gastric Atresia; Gastric Volvulus; Congenital Microgastria; Gastric Diverticulum; Gastric Duplication Cysts; Teratomas; Motility; Adult/Acquired Clinical Disorders; Surface Pit Cells; Enteroendocrine Cells; Parietal Cells; Zymogenic (Chief) Cells; Future Questions; Acknowledgments; References; Chapter 6 The Pylorus: Development and Disease; Introduction; Pyloric Morphology; Pyloric Pathologies |
| Summary |
Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of rese |
| Notes |
Duodenogastric Reflux |
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Print version record |
| Subject |
Digestive organs.
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Digestive organs -- Diseases.
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Morphogenesis.
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Digestive System -- growth & development
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Digestive System Diseases
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Organogenesis
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Digestive System
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Digestive organs
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Digestive organs -- Diseases
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Morphogenesis
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| Form |
Electronic book
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| Author |
Samuelson, Linda C
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Spence, Jason R
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| ISBN |
9781118492895 |
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1118492897 |
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