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Book Cover
Author Takayama, Yoshiharu

Title Lactoferrin and its role in wound healing / Yoshiharu Takayama
Published Dordrecht : Springer, ©2012


Description 1 online resource (ix, 107 pages) : illustrations
Contents Lactoferrin and its Role in Wound Healing; Preface; Contents; Chapter 1: Molecular Regulation of Skin Wound Healing; 1.1 Introduction; 1.2 Immediate Response; 1.3 Inflammatory Response; 1.4 Reepithelialization; 1.5 Granulation Tissue Formation; 1.6 Wound Contraction; 1.7 Angiogenesis; 1.8 Remodeling; 1.9 Resolution of Inflammation; 1.10 Proteases in Wound Healing; 1.11 Anti-microbial Peptides; 1.12 Chronic Wound Healing; References; Chapter 2: Role of Hyaluronan in Wound Healing; 2.1 Structure; 2.2 Biosynthesis; 2.3 Hyaluronan Receptor; 2.4 Mammalian Hyaluronidase; 2.5 Hyaluronan Fragment
2.6 Role on Cancer2.7 Hyaluronan in Dermis and Epidermis; 2.8 Role on Wound Healing; References; Chapter 3: Lactoferrin Structure Function and Genetics; 3.1 Introduction; 3.2 Lactoferrin Expression and Localization; 3.3 Lactoferrin Structure; 3.4 Iron-Binding Properties of Lactoferrin; 3.5 Lactoferrin Metabolism; 3.6 Anti-bacterial Activity of Lactoferrin; 3.7 Bactericidal Activity of Lactoferrin Derived Peptides; 3.8 Anti-viral Activity of Lactoferrin; 3.9 Anti-parasitic and Anti-fungal Activity of Lactoferrin; 3.10 Immunoregulatory Properties of Lactoferrin
3.11 Anti-inflammatory Activity of Lactoferrin3.12 Anti-oxidative Effect of Lactoferrin; 3.13 Genetics; 3.14 Other Functions; References; Chapter 4: Lactoferrin as a Signaling Mediator; 4.1 Introduction; 4.2 Intestinal Lactoferrin Receptor (Intelectin); 4.3 LDL Receptor Related Protein (LRP); 4.4 Hepatocyte Lactoferrin Receptor; 4.5 Nucleolin; 4.6 Monocytes and Macrophage Lactoferrin Receptor; 4.7 Dendritic Cell Lactoferrin Receptor; 4.8 Lymphocytes Lactoferrin Receptor; 4.9 Cell Cycle Control and Apoptosis Induction; 4.10 Angiogenesis; 4.11 Fibroblasts; 4.12 Osteogenic Differentiation
4.13 Osteoclasts4.14 Chondrogenic Differentiation; 4.15 Adipogenesis; 4.16 Lactoferrin Receptor in Brain Capillary Endothelial Cells; 4.17 Platelet Lactoferrin Receptor; 4.18 Lactoferrin Receptor in Epithelial Cells; 4.19 Lactoferrin Receptor in Respiratory Epithelial Cells; 4.20 Transcription Regulator; References; Chapter 5: Effects of Lactoferrin on Skin Wound Healing; 5.1 Introduction; 5.2 Cell Proliferation and Migration; 5.3 Collagen Gel Contraction by Fibroblasts; 5.4 Molecular Mechanism of Wound Healing; 5.5 Regulation of Cell Adhesion; 5.6 Hyaluronan Synthesis
5.7 Production of Extracellular Matrix Components5.8 Corneal Epithelia Wound Healing; 5.9 Talactoferrin; 5.10 Cutaneous Immunity; 5.11 Anti-apoptotic Effect; 5.12 Diabetic Ulcers; References; Index
Summary Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lacto
Analysis Medicine
Human physiology
Cell receptors
Cell membranes
Cell Biology
Protein Science
Bibliography Includes bibliographical references and index
Notes English
Subject Wound healing.
Lactoferrin -- Therapeutic use
Regeneration (Biology)
Life sciences.
Physical sciences.
Carrier proteins.
Milk proteins.
Lactoferrin -- physiology
Iron-Binding Proteins
Biological Science Disciplines
Natural Science Disciplines
Biological Phenomena
Carrier Proteins
Milk Proteins
Amino Acids, Peptides, and Proteins
Dietary Proteins
Disciplines and Occupations
Phenomena and Processes
Chemicals and Drugs
Wound Healing
Lactoferrin -- therapeutic use
Wound Healing -- physiology
biological sciences.
physical sciences.
MEDICAL -- Surgery -- General.
Regeneration (Biology)
Physical sciences
Milk proteins
Life sciences
Carrier proteins
Wound healing
Form Electronic book
LC no. 2011939477
ISBN 9789400724679