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Title Glucokinase and glycemic disease : from basics to novel therapeutics / volume editors, F.M. Matschinsky, M.A. Magnuson
Published Basel ; New York : Karger, 2004


Description 1 online resource (ix, 406 pages) : illustrations
Series Frontiers in diabetes, 0251-5342 ; v. 16
Frontiers in diabetes ; v. 16. 0251-5342
Contents Preface / Matschinsky, F.M.; Magnuson, M.A. -- Chapter 1. Background -- Glucokinase as a Glucose Sensor : Past, Present and Future / Magnuson, M.A.; Matschinsky, F.M. -- The Hexokinase Gene Family / Wilson, J.E. -- Comparative Biochemistry of Glucokinase / Cardenas, M.L. -- Chapter 2. Human Biomedical Studies -- Maturity Onset Diabetes of the Young Type 2 / Velho, G. [and others] -- Permanent Neonatal Diabetes mellitus due to Glucokinase Deficiency / Njolstad, P.R. [and others] -- Glucokinase-Linked Hypoglycemia : Clinical Aspects of Activating Glucokinase Mutations / Christesen, H.B.T. [and others] -- Glucokinase and the Regulation of Blood Sugar : A Mathematical Model Predicts the Threshold for Glucose Stimulated Insulin Release for GCK Gene Mutations that Cause Hyper- and Hypoglycemia / Gloyn, A.L. [and others] -- Glucokinase/Glutamate Dehydrogenase Interactions in the GDH form of Congenital Hyperinsulinism / Kelley, A.; Li, C.; Stanley, C.A. -- Chapter 3. Structure and Function -- Glucokinase : A Monomeric Enzyme with Positive Cooperativity / Cornish-Bowden, A.; Cardenas, M.L. -- Molecular Models of Human Glucokinase and the Implications for Glycemic Diseases / Harrison, R.W.; Weber, I.T. -- Crystal Structure of Human Liver Glucokinase Bound to a Small Molecule Allosteric Activator : Insights into the Activating Mutations / Dunten, P. [and others] -- Chapter 4. Regulation of Glucokinase -- Molecular Biology of Glucokinase Regulation / Iynedjian, P.B. -- Role of the Transcription Factor Sterol Regulatory Element Binding Protein-1c in Hepatic Glucokinase Gene Regulation / Foufelle, F.; Ferre, P. -- Regulation of Hepatic Glucokinase Gene Expression / Postic, C.; Decaux, J.-F.; Girard, J. -- Discovery and Role of Glucokinase Regulatory Protein / van Schaftingen, E.; Veiga da Cunha, M. -- GKRP/GK: Control of Metabolic Fluxes in Hepatocytes / Agius, L. [and others] -- Regulation of Glucokinase as Islets Adapt to Pregnancy / Sorenson, R.L.; Weinhaus, A.J.; Brelje, T.C. -- Regulation of Glucokinase by Vitamins and Hormones / Fernandez-Mejia, C.; German, M.S. -- Regulation of [beta]-Cell GK Gene Transcription by Insulin / Leibiger, B.; Berggren, P.-O.; Leibiger, I.B. -- Interaction of GK with the Bifunctional Enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (6PF2K/F26P2ase) / Baltrusch, S. [and others] -- Role of Sulfhydril Groups in GK Catalysis for GK Function / Tiedge, M.; Baltrusch, S.; Lenzen, S. (Hannover) -- Chapter 5. Tissue-Specific Functions -- Mouse Models of Altered Glucokinase Gene Expression / Magnuson, M.A.; Kim, K.-A. -- Anatomy, Physiology and Regulation of Glucokinase as a Brain Glucosensor / Levin, B.E. [and others] -- A Glucokinase/AP-1 Glucose Transduction Mechanism in the Ventromedial Hypothalamic Satiety Center / Yang, X.-j. [and others] -- The Hepatoportal Glucose Sensor : Mechanisms of Glucose Sensing and Signal Transduction / Thorens, B. -- Linear Relationship between Glucokinase Expression, Metabolic Redox State and Insulin Secretion / Piston, D.W.; Patterson, G.H. -- Glucokinase in [beta]-Cell Insulin-Secretory Granules / Miwa, I.; Toyoda, Y.; Yoshie, S.-- Chapter 6: Glucokinase as Drug Target -- Discovery and Actions of Glucokinase Activators / Grimsby, J.; Matschinsky, F.M.; Grippo, J.F. -- Balancing Hepatic Glucose Disposal and Production : Key Regulatory Genes and Therapeutic Opportunities / Yang, R.; Newgard, C.B
Summary The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus. The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the enzymology, structure and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that discuss the diverse roles of the enzyme in a variety of tissues. Finally, the book contains the latest information on the recently discovered class of weight drugs that activate glucokinase (i.e. glucokinase activators or GKAs). This volume is of great interest to basic and clinical diabetes researchers, geneticists, biochemists, physiologists and pharmacologists
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Print version record
Subject Glucokinase.
Glucose Metabolism Disorders -- metabolism
Glucose Metabolism Disorders -- therapy
Diabetes Mellitus
Glucokinase -- metabolism
Glucokinase -- therapeutic use
Models, Molecular
HEALTH & FITNESS -- Diseases -- Diabetes.
Glucokinase -- Physiologie -- Aufsatzsammlung.
Diabetes mellitus -- Pharmakotherapie -- Aufsatzsammlung.
Pharmakotherapie -- Diabetes mellitus -- Aufsatzsammlung.
Form Electronic book
Author Matschinsky, F. M. (Franz M.)
Magnuson, M. A. (Mark A.)
ISBN 1417564911