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Title Diabetes and viruses / Keith Taylor [and others], editors
Published New York, NY : Springer, ©2013


Description 1 online resource : illustrations (some color)
Contents Part 1. Background and Pathogenesis -- Historical Background: Earlier Studies on the Connexion Between Viruses and Diabetes / Keith W. Taylor -- Viruses and Autoimmune Diabetes: A History / R. David G. Leslie, Lily Ho-Le and Huriya Beyan -- Genetics of Type 1 Diabetes / Robert Hermann and Jorma Ilonen -- Non-Genetic Factors in the Pathogenesis of Type 1 Diabetes / Serena Wai-Yan Chiu, R. David G. Leslie and Huriya Beyan
Part 2. Studies in Animals -- Encephalomyocarditis Virus / Seiho Nagafuchi, Hironori Kurisaki and Hitoshi Katsuta -- Enteroviruses in the Mouse Model of Type 1 Diabetes / Nora M. Chapman -- Viruses and Autoimmune Diabetes in Rats / John P. Mordes, Danny Zipris, Zhijun Liu and Elizabeth P. Blankenhorn -- Reovirus / Takashi Onodera and Toshiharu Hayashi -- Ljungan Virus and Diabetes / Martin Blixt, Stellan Sandler and Bo Niklasson -- Virus-Related Diabetes in Cattle / Kazuya Matsuda and Hiroyuki Taniyama
Part 3. Studies in Humans -- Epidemiology of Viruses in Type 1 Diabetes: Seasonal Incidence, Family Studies, Clustering / Keith W. Taylor -- Molecular Biology and Classification of Enteroviruses / Glyn Stanway -- Laboratory Diagnosis of Enterovirus Infection: Optimal Methods for Studies of Diabetes / Sami Oikarinen and Maarit Oikarinen -- Enterovirus Immunity and the "Hygiene Hypothesis" / Heikki Hyöty -- Enteroviruses in Blood / Antonio Toniolo, Alessandro Salvatoni, Giovanni Federico, Giuseppe Maccari and Oscar Díaz-Horta, et al. -- Coxsackieviruses and Insulitis / Letizia Galleri, Fabio Arturo Grieco, Guido Sebastiani, Isabella Spagnuolo and Francesco Vendrame, et al. -- Viruses in the Human Pancreas / S.J. Richardson, A. Willcox, A.J. Bone, N.G. Morgan and A.K. Foulis -- Rotavirus and Type 1 Diabetes / Margo C. Honeyman and Leonard C. Harrison -- Viruses, Diabetes, and Autoimmunity: Studies of Subjects at Genetic Risk for Type 1 Diabetes / Sabina Resic Lindehammer and Åke Lernmark -- Type 1 Diabetes in the Tropics: A Link with Enterovirus Infections / Eduardo Cabrera-Rode, Oscar Díaz-Horta, Antonio Toniolo and Luis Sarmiento -- Diabetes and Viruses in Australia and the Asia-Pacific Region / Myra Poon, William D. Rawlinson and Maria E. Craig -- Fulminant Type 1 Diabetes in Japan / Akihisa Imagawa and Toshiaki Hanafusa
Part 4. Evaluation of causality in human studies -- Defining Causal Relationships Between Viral Infections and Human Diabetes / Lars C. Stene and Marian Rewers -- The JDRF Network for the Pancreatic Organ Donor with Diabetes (nPOD): A novel Resource and Study Approach in Type 1 Diabetes Research / Alberto Pugliese, Martha Campbell-Thompson, Teodora Staeva and Mark A. Atkinson
Part 5. Possible Mechanisms -- Virus-Induced Models for Type 1 Diabetes in Mice / Urs Christen and Matthias G. von Herrath -- The Role of T Lymphocytes in the Pathogenesis of Autoimmune Type 1 Diabetes: Implications for Potential Virus-Mediated Pathways / Martin Eichmann and Mark Peakman -- Innate Immune Responses to Viruses Inducing Diabetes / Katharina Lind and Malin Flodström Tullberg -- Enterovirus Infection of Cultured Human Pancreatic Islets / Teemu Smura and Merja Roivainen -- Innate Immunity of Human Pancreatic Islets Infected with Different Enterovirus Types / Gun Frisk -- Antibody-Dependent Enhancement of Coxsackievirus-B Infection: Role in the Pathogenesis of Type 1 Diabetes / Didier Hober, Famara Sane, Karena Riedweg, Rachel Desailloud and Anne Goffard
Part 6. Perspectives -- Speculation on Prevention of Type 1 Diabetes / Richard Insel -- Viruses as Major Environmental Factors in the Induction of Diabetes / Heikki Hyöty and Keith W. Taylor -- Reflections on Viruses and Diabetes Mellitus / Arie J. Zuckerman
Summary Diabetes, in all of its forms, now constitutes a growing health concern, affecting all segments of the world's population. There is great interest in the factors which influence its etiology and progression. Among these, a number of viruses feature prominently. Hindered by technological limitations, research into this relationship has hitherto been scarce. Recent advances, however, have opened up the field and there is a burgeoning body of literature on the subject. Unfortunately, this literature has been diffuse and often difficult to access. For the first time, this book compiles the views of many of the world's experts in the field. It addresses questions, ranging from how viruses may destroy or modify the function of pancreatic islets; to which viruses are the most likely culprits; to whether vaccines or etiologic therapies might be used to prevent virus-induced diabetes. Diabetes and Viruses is the first comprehensive volume on an important and expanding field of research that is of interest to clinicians, healthcare managers, epidemiologists, veterinarians, and basic scientists
Analysis Medicine
Medical virology
Emerging infectious diseases
Infectious Diseases
Bibliography Includes bibliographical references and index
Subject Immunology.
Emerging infectious diseases.
Diabetes -- Immunological aspects
Medical virology.
Diabetes Mellitus -- etiology
Diabetes Mellitus -- immunology
Diabetes Mellitus, Type 1 -- immunology
Virus Diseases -- complications
Allergy and Immunology
Communicable Diseases, Emerging
HEALTH & FITNESS -- Diseases -- Diabetes.
Diabetes -- Immunological aspects
Emerging infectious diseases
Medical virology
Form Electronic book
Author Taylor, K. W. (Keith William)
ISBN 9781461440512