| Description |
1 online resource (xv, 732 pages) : illustrations |
| Series |
Springer protocols |
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Neuromethods, 1940-6045 ; 48 |
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Springer protocols (Series)
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Neuromethods ; 48. 0893-2336
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| Contents |
General introduction to animal models of human conditions / Peter Paul De Deyn and Debby Van Dam -- Animal models of dementia : ethical considerations / I. Anna S. Olsson and Peter Sandøe -- The role of rodent models in the drug discovery pipeline for dementia / Debby Van Dam and Peter Paul De Deyn -- Species, strain, and gender issues in the development and validation of animal models of dementia / Annemie Van Dijck, Debby Van Dam, and Peter Paul De Deyn -- Transgenic and gene targeted models of dementia / Ronald A. Conlon -- Transgenic animals and intellectual property concerns / Susan L. Stoddard and James A. Rogers III -- Pathological validation of animal models of dementia / Daniel Pirici, Christine Van Broeckhoven, and Samir Kumar-Singh -- Behavioral validation in animal models of dementia / Debby Van Dam, Annemie Van Dijck, and Peter Paul De Deyn -- Pharmacological validation in animal models of dementia / Hugo Geerts -- Validation of animal models of dementia : neurochemical aspects / Giancarlo Pepeu and Maria Cristina Rosi -- Validation of dementia models employing neuroimaging techniques / Greet Vanhoutte, Adriaan Campo, and Annemie Van der Linden -- Drosophila melanogaster as a model organism for dementia / Maria E. Giannakou and Damian C. Crowther -- Caenorhabditis elegans as a model organism for dementia / Tjakko J. Van Ham and Ellen A.A. Nollen -- Zebrafish (Danio rerio) as a model organism for dementia / Rob Willemsen [and others] -- Spontaneous vertebrate models of Alzheimer dementia : selectively bred strains (SAM strains) / Renã A. Sowell and D. Allan Butterfield -- Lesion-induced vertebrate models of Alzheimer dementia / Adolfo Toledano and Maria Isabel Álvarez -- A[Beta] infusion and related models of Alzheimer dementia / Patricia A. Lawlor and Deborah Young -- APP-based transgenic models : the PDAPP model / Jacob M. Basak and David M. Holtzman -- APP-based transgenic models : the Tg2576 model / Robert M.J. Deacon -- APP-based transgenic models : the APP23 model / Debby Van Dam and Peter Paul De Deyn -- Presenilin-based transgenic models of Alzheimer's dementia / Yuji Yoshiike and Akihiko Takashima -- APOE-based models of "pre-dementia" / Patrick M. Sullivan -- TAU models / Nicolas Sergeant and Luc Buée -- The 3xTg-AD mouse model : reproducing and modulating plaque and tangle pathology / Michael Sy, Masashi Kitazawa, and Frank LaFerla -- Cognitive dysfunction in genetic mouse models of parkinsonism / Sheila M. Fleming, J. David Jentsch, and Marie-Françoise Chesselet -- Mouse models of metachromatic leukodystrophy and adrenoleukodystrophy / Patrick Aubourg, Caroline Sevin, and Nathatie Cartier -- Animal models of amyotrophic lateral sclerosis / Ludo Van Den Bosch -- Animal models of frontotemporal dementia / Hana N. Dawson and Daniel T. Laskowitz -- CADASIL : molecular mechanisms and animal models / Karl J. Fryxell -- Spontaneously hypertensive rat (SHR) : an animal model of vascular brain disorder / Francesco Amenta and Daniele Tomassoni -- Animal models of normal pressure hydrocephalus / Petra M. Klinge -- Animal models of traumatically-induced dementia / Jennifer E. Slemmer, Mohammad Z. Hossain, and John T. Weber -- Animal models of alcohol-induced dementia / Angela Maria Ribeiro and Silvia R. Castanheira Pereira -- Animal models of metallic dementia / Luigi F. Rodella |
| Summary |
With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer's disease, Parkinson's disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research |
| Analysis |
neurologie |
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neurology |
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diermodellen |
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animal models |
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biomedische wetenschappen |
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biomedicine |
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neurowetenschap |
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neuroscience |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Dementia -- Animal models
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Brain -- Diseases -- Animal models
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Dementia -- Treatment -- Research
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Brain -- Diseases -- Animal models
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Dementia -- Animal models
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| Genre/Form |
Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Deyn, P. P. de (Peter P.)
|
|
Dam, Debby van.
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| ISBN |
9781607618980 |
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1607618982 |
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