| Description |
1 online resource (xiii, 184 pages) : illustrations |
| Contents |
1. Background -- 2. Conventional statistics -- 3. Statistics used in adaptive clinical trials -- 4. Specific requirements for adaptive trials -- 5. Adaptive randomization and allocation -- 6. Sample size reestimation -- 7. Traditional dosing -- 8. Adaptive dosing -- 9. Interim analysis and adaptive termination of study and study arms -- 10. Adaptive changes in study design and decision rules -- 11. Seamless designs and adaptive clinical trial conduct -- 12. Analysis and interpretation of results |
| Summary |
Adaptive clinical trial designs, unlike traditional fixed clinical trial designs, enable modification of studies in response to the data generated in the course of the trial. This often results in studies that are substantially faster, more efficient, and more powerful. Recent developments in web-based real-time data entry and advances in statistical methods have made adaptive clinical trials much more popular because they have become both more practical and attractive. However, there is paucity of resources that explain the mathematical framework and the practical considerations for adaptive |
| Notes |
"A Chapman & Hall book." |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Clinical trials.
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Clinical Trials as Topic
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Database Management Systems -- trends
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Efficiency, Organizational
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Research Design
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BODY, MIND & SPIRIT -- Healing -- General.
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HEALTH & FITNESS -- Alternative Therapies.
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HEALTH & FITNESS -- Healing.
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MEDICAL -- Healing.
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Clinical trials
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| Form |
Electronic book
|
| ISBN |
9781439838334 |
|
143983833X |
|
