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E-book

Title Oxidative damage to nucleic acids / [edited by] Mark D. Evans, Marcus S. Cooke
Published Austin, Tex. : Landes Bioscience ; New York : Springer Science+Business Media, ©2007

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Description 1 online resource (228 pages) : illustrations
Series Molecular biology intelligence unit
Molecular biology intelligence unit (Unnumbered)
Contents Oxidatively generated damage to cellular DNA : mechanistic aspects / Jean Cadet [and others] -- Chlorination and nitration of DNA and nucleic acid components / Clare L. Hawkins [and others] -- Prevention of the mutagenicity and cytotoxicity of oxidized purine nucleotides / Yusaku Nakabeppu [and others] -- Nucleotide incision repair : an alternative and ubiquitous pathway to handle oxidative DNA damage / Sophie Couvé-Privat [and others] -- OGG1 : from structural analysis to the knockout mouse / Arne Klungland, Jon K. Laerdahl, and Torbjörn Rognes -- Processing of 3'-end modified DNA strand breaks induced by oxidative damage / Jason L. Parsons, Emma Boswell, and Grigory L. Dianov -- Oxidative damage and promoter function / David Mitchell and Rita Ghosh -- Oxidative DNA damage and telomere shortening / Torsten Richter and Thomas von Zglinicki -- Oxidative damage and repair in the mitochondrial genome / Lene Juel Rasmussen and Keshav K. Singh. -- The role of oxidative damage to nucleic acids in the pathogenesis of neurological disease / V. Prakash Reddy [and others] -- Nucleic acid oxidation and the pathogenesis of cardiovascular diseases / Maria Grazia Andreassi -- Oxidative DNA damage and carcinogenesis / Ryszard Olinski, Marek Foksinski, and Barbara Tudek -- The physiological and pathological roles of oxidative damage to DNA in relation to life stage / Alberto Izzotti -- Analysis of 8-hydroxy-2'-deoxyguanosine as a marker of oxidatively damaged DNA in relation to carcinogenesis and aging / H. Kasai [and others] -- Oxidatively damaged DNA and inflammation / Peter C. Dedon and Marita C. Barth -- The role of antioxidants in the prevention of oxidative damage to nucleic acids / Peter Muller and Steffen Loft
Summary This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, we have included some areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, we recognize additionally the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. The primary audience for the book would be research scientists and advanced postgraduate students, the book may also be of interest to clinicians with strong research interests. We would expect readers to come away from this book with a greater appreciation of the topic, particularly appraising the reader of areas that may not necessarily have been covered in such a volume before
Analysis nucleic acids
biochemie
biochemistry
Nucleic Acids
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Nucleic acids -- Oxidation
DNA repair.
Chemical mutagenesis.
DNA damage.
Oxidative stress.
DNA Damage
Oxidative Stress
Antioxidants -- therapeutic use
DNA Repair Enzymes
DNA Repair
Biomédecine.
Sciences de la vie.
Oxidative stress
DNA damage
Chemical mutagenesis
DNA repair
Ácidos nucléicos.
Estresse oxidativo.
Citologia (fisiologia)
Dna (lesões)
Form Electronic book
Author Evans, Mark D. (Mark Dennis), 1962-
Cooke, Marcus S.
LC no. 2007024908
ISBN 9780387729749
0387729747