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Book Cover
Author Pardee, Joel D.

Title The actin cytoskeleton in cell motility, cancer, and infection / Joel D. Pardee
Published [San Rafael, Calif.] : Morgan & Claypool Life Sciences, ©2010


Description 1 online resource (xi, 57 pages) : illustrations
Series Colloquium series on the cell biology of medicine ; #3
Colloquium series on the cell biology of medicine ; bk. #3.
Contents The cytoskeleton -- How cells move -- Regulation of the actin cytoskeleton -- The role of myosin in cell motility -- The role of cell adhesion in cell motility -- Recommended readings
Summary By now it is abundantly clear that the cells of our bodies have the ability to move because of their actin cytoskeleton. From the earliest cell migrations in the embryo that serve to form the primordial tissue layers to the outgrowth of neurons, the contractions of our heart and skeletal muscles, and the metastasis of cancer cells, it is the regulated action of the actin cytoskeleton that propels our various motions. In this chapter we will examine the biochemical and cell biological mechanisms that control actin-based cell motility. We will see that cell migration along a substratum occurs in three fundamental phases that are exquisitely orchestrated in sequence. Cell migration occurs by an initial extension of the front edge of the cell, followed closely by contraction of the cell's rear end to push cytoplasm into the newly formed extension. As the cell's new leading edge extends, attachment sites are assembled on the cell floor, and extend through the plasma membrane to couple the migrating cell to the underlying surface. How the cell knows where to go, when to detach and reattach during the migration, and how to keep each process under strict control is a story well worth hearing, because it is motility and adhesion that make a multicellular life such as ours possible
Bibliography Includes bibliographical references
Notes Print version record
Subject Cytoskeletal proteins.
Cells -- Motility.
Cell Movement
Cytoskeletal Proteins
SCIENCE -- Life Sciences -- Cell Biology.
Cells -- Motility
Cytoskeletal proteins
Form Electronic book
ISBN 9781615040070