| Description |
1 online resource (xxiv, 453 pages) : illustrations (some color) |
| Contents |
Part 1. Basics of the Cytoskeleton -- ACTIN / Vera Dugina, Richard Arnoldi, Paul A. Janmey and Christine Chaponnier -- Microtubules / Pavel Dráber and Eduarda Dráberová -- The Kinesin Superfamily / Linda Wordeman -- Basics of the Cytoskeleton: Myosins / Omar A. Quintero, Judy E. Moore and Christopher M. Yengo -- Part 2. Actin and Disease -- The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes / Rhea Cornely, Thomas Grewal and Katharina Gaus -- Thin Filament Diseases of Striated Muscle / Anthony J. Kee and Edna C. Hardeman -- Filamins and Disease / Stephen P. Robertson and Philip B. Daniel -- LIM Kinase and Cancer Metastasis / Alice Schofield and Ora Bernard -- Actin Mutations and Deafness / Matías Morín, Fernando Mayo, Felipe Moreno and Miguel A. Moreno-Pelayo -- Therapeutic Targeting of the Actin Cytoskeleton in Cancer / Teresa Bonello, Jason Coombes, Galina Schevzov, Peter Gunning and Justine Stehn |
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Part 3. Microtubules and Disease -- Microtubules as a Target in Cancer Therapy / April L. Risinger and Susan L. Mooberry -- Microtubules, Drug Resistance, and Tumorigenesis / Joshua A. McCarroll and Maria Kavallaris -- Posttranslational Modifications of Tubulin / Suzan K. Chao, Chia-Ping H. Yang and Susan Band Horwitz -- Stathmin and Cancer / Dominic Chi Hiung Ng and Frances Byrne -- The Biology and Pathobiology of Tau Protein / Garth F. Hall -- Tubulin-Related Malformations of Cortical Development / Xavier H. Jaglin, Jamel Chelly and Nadia Bahi-Buisson -- Part 4. Intermediate Filaments and Disease -- Spectrins in Human Diseases / Marie-Christine Lecomte -- Laminopathies / Nadir M. Maraldi and Giovanna Lattanzi -- Desmin and Heart Disease / J. Scott Pattison and Jeffrey Robbins -- Neurodegenerative Diseases and Intermediate Filaments / Rodolphe Perrot and Jean-Pierre Julien |
| Summary |
The cytoskeleton is made up of a large variety of specialized proteins and is a highly dynamic system that is involved in the majority of key cellular events. It is now clear that the cytoskeleton is often associated, and has diverse roles in human disease.¡ Emerging understanding of the molecular and cellular events that drive cytoskeletal mediated disease including cancer, heart disease, myopathies, neurodegenerative diseases and skin disorders, are also helping shape targeted therapeutic approaches to treat these diseases. ¡ Cytoskeleton and Human Disease Book Summary reviews the key components, mechanisms and clinical implications of cytoskeletal defects in disease. Contributed by leading investigators in their respective fields, the chapters include topics associated with the basics of the cytoskeleton, actin-associated disease states, microtubule-associated disease states and intermediate filament-associated disease states. ¡ This authoritative volume is intended for a wide audience of clinicians, researchers and students with an interest in the application of biomedical research to the understanding and management of disease states associated with the cytoskeleton |
| Analysis |
Life sciences |
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Oncology |
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Biochemistry |
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Cytology |
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Cell cycle |
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Cell Biology |
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Cell Cycle Analysis |
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Cell Physiology |
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Biochemistry, general |
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Cancer Research |
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humane ziekten |
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human diseases |
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celskelet |
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cytoskeleton |
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celbiologie |
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cellular biology |
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biochemie |
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neoplasms |
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celfysiologie |
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celcyclus |
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Human Pathology |
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Humane pathologie |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Cytoskeleton.
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Pathology, Cellular.
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Cytoskeleton -- pathology
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Cytoskeleton -- genetics
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Cytoskeleton
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MEDICAL -- Histology.
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Cytoskeleton
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Pathology, Cellular
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| Form |
Electronic book
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| Author |
Kavallaris, Maria
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| ISBN |
9781617797880 |
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161779788X |
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1617797871 |
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9781617797873 |
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