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Title Chemoattractant ligands and their receptors / edited by Richard Horuk
Published Boca Raton : CRC Press, ©1996


Description 1 online resource (377 pages) : illustrations (some color)
Series Pharmacology and toxicology
Pharmacology & toxicology (Boca Raton, Fla.)
Contents The role of interleukin-8 in inflammatory diseases / V. Courtney Broaddus and Caroline A. Hebert -- Structure-function relationships of IL-8 and its two neutrophil receptors: IL-8-RA and IL-8-RB / Caroline A. Hebert and Henry B. Lowman -- Three-dimensional structures of the chemokine family / Wayne J. Fairbrother and Nicholas J. Skelton -- Melanoma growth stimulatory activity: physiology, biology, structure/function, and role in disease / Ann Richmond and Rebecca L. Shattuck
(Continued) The Duffy antigen receptor for chemokines / Richard Horuk and Stephen C. Peiper -- Biology, biochemistry, and pathophysiology of the RANTES chemokine / Peter J. Nelson, James M. Pattison, and Alan M. Krensky -- The monocyte chemoattractant protein family / Alberto Mantovani [and others] -- The macrophage inflammatory protein family / Stewart Craig and Ronald Hoffman
(Continued) C-C chemokine receptors / Kuldeep Neote and Shaun R. McColl -- Chemotactic factor receptors and signal transduction / Shaun R. McColl and Kuldeep Neote -- Arachidonic acid-derived bioactive lipids and their role in human disease states / H. Daniel Perez -- The [nu]-formylpeptide chemotactic receptor / Philip M. Murphy -- Mechanism of chemokine-induced leukocyte adhesion and emigration / Elin Hub, James Middleton, and Antal Rot
(Continued) Viral chemokine receptors / Philip M. Murphy, Sunil K. Ahuja, and Ji-Liang Gao -- Chemokine receptors in the brain: hierarchical expression by subsets of neurons / Stephen C. Peiper and Richard Horuk
Summary Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. Written by acknowledged experts in the field, it contains detailed molecular and structural information on each of the major chemoattractants and their receptors. Its unique multidisciplinary approach encompasses biology, immunology, protein chemistry, and molecular biology. A time-saving reference for both researchers and students
Bibliography Includes bibliographical references and index
Notes Richard Horuk, Ph. D., is a Senior Scientist in the Department of Immunology at Berlex BioSciences, Richmond, California. Dr. Horuk received his B. Sc. Degree in Applied Biology from Trent Polytechnic, Nottingham, U.K., in 1977 and his Ph. D. Degree in Biochemistry in 1980 from Birkbeck College, University of London, U.K. He was a Postdoctoral fellow from 1981 to 1983 working in the laboratory of Dr. Martin Rodbell at the National Institutes of Health, Bethesda, Maryland. In 1983 he joined Dr. Jerrold Olefsky's laboratory at the University of California San Diego to pursue further studies on insulin action, after which he was appointed as an assistant researcher. In 1986 Dr. Horuk was appointed Principal Scientist at the Dupont Company in Glenolden, Pennsylvania, where he undertook research on interleukin-1 receptors and was the first to discover both the type II IL-1 receptor and the soluble IL-1 receptor. From 1991 to 1994 Dr. Horuk was in the Department of Protein Chemistry, Genentech, California. Here Dr. Horuk started a research program centered on chemokines and their receptors and was the first to discover that the Duffy Antigen, a portal of entry for the malarial parasite Plasmodium vivax, was also a chemokine receptor. Dr. Horuk joined Berlex BioSciences in 1994 and presently leads a major program on chemokine receptor research. Dr. Horuk is a member of the American Society of Biochemistry and Molecular Biology, the American Association of Immunologists, the Protein Society, the International Cytokine Society, and the American Association for the Advancement of Science. Dr. Horuk has presented numerous invited lectures at international and national meetings on chemokines and has published more than 80 research papers. His current research interests involve the role of chemokines in disease and the implementation of various therapeutic interventions
Print version record
Subject Ligand
Chemokines -- Receptors
Cell receptors.
Receptors, Cell Surface
Chemotactic Factors
MEDICAL -- General.
MEDICAL -- Immunology.
SCIENCE -- Life Sciences -- Cytology.
Cell receptors
Form Electronic book
Author Horuk, Richard.
ISBN 9780367812539