| Description |
1 online resource (653 pages) |
| Contents |
Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Acknowledgements -- Commonly Used Abbreviations -- Chapter 1 The Nature of Leukaemia, Cytology, Cytochemistry and the Morphological Classification of Acute Leukaemia -- The nature of leukaemia -- The aetiology of leukaemia -- The importance of classification -- The nature and classification of acute leukaemia -- The nature and classification of the myelodysplastic syndromes -- The nature and classification of chronic myeloid leukaemias and myelodysplastic/myeloproliferative neoplasms -- The nature and classification of lymphoid neoplasms -- Defining a blast cell, a promyelocyte and a promonocyte -- The FAB classification of acute leukaemia -- Diagnosing acute leukaemia -- Distinguishing between acute myeloid and acute lymphoblastic leukaemias -- Defining remission -- The incidence of acute leukaemia -- The FAB categories and other morphological categories of acute myeloid leukaemia -- Acute myeloid leukaemia with minimal evidence of myeloid differentiation: M0 acute myeloid leukaemia -- Acute myeloid leukaemia without maturation: M1 acute myeloid leukaemia -- Acute myeloid leukaemia with maturation: M2 acute myeloid leukaemia -- Acute hypergranular promyelocytic leukaemia: M3 acute myeloid leukaemia -- The variant form of acute promyelocytic leukaemia: M3 variant acute myeloid leukaemia -- Acute myelomonocytic leukaemia: M4 acute myeloid leukaemia -- Acute monocytic/monoblastic leukaemia: M5 acute myeloid leukaemia -- Acute myeloid leukaemia with predominant erythroid differentiation: M6 acute myeloid leukaemia -- Acute megakaryoblastic leukaemia: M7 acute myeloid leukaemia -- Acute eosinophilic leukaemia -- Acute basophilic leukaemia -- Acute mast cell leukaemia -- Langerhans cell leukaemia -- Hypoplastic or hypocellular acute myeloid leukaemia |
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Clinical correlates of FAB categories of acute myeloid leukaemia -- The FAB classification of acute lymphoblastic leukaemia -- 'Acute lymphoblastic leukaemia' of L3 subtype -- Automated full blood counts in acute leukaemia -- References -- Chapter 2 Immunophenotyping and Cytogenetic/Molecular Genetic Analyis -- Introduction -- Immunophenotyping -- Problems and pitfalls in immunophenotyping -- Immunophenotype of normal haemopoietic cells -- Immunophenotyping in acute leukaemia -- Immunophenotyping in acute myeloid leukaemia -- Immunophenotyping in acute lymphoblastic leukaemia -- Immunophenotyping in mixed phenotype acute leukaemia -- Immunophenotyping in myelodysplastic syndromes, myeloproliferative neoplasms and overlap syndromes -- Immunophenotyping in myelodysplastic syndromes -- Immunophenotyping in myelodysplastic/myeloproliferative neoplasms -- Immunophenotyping in myeloproliferative neoplasms -- Immunophenotyping in suspected B-lineage lymphoproliferative disorders -- Immunophenotyping in suspected T-lineage lymphoproliferative disorders -- Immunophenotyping in suspected natural killer-lineage lymphoproliferative disorders -- Genetic analysis -- Cytogenetic analysis -- Problems and pitfalls in cytogenetic analysis -- FISH and comparative genomic hybridisation -- Problems and pitfalls in FISH analysis -- Molecular genetic analysis -- Problems and pitfalls in molecular genetic analysis -- The role of cytogenetic and molecular genetic analysis in haematological neoplasms -- Problems and pitfalls in cytogenetic and molecular genetic analysis -- Cytogenetic and molecular genetic analysis in acute leukaemia -- Measurable residual disease in acute leukaemia -- Cytogenetic and molecular genetic analysis in acute myeloid leukaemia -- Cytogenetic and molecular genetic analysis in acute lymphoblastic leukaemia -- Conclusions -- References |
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Chapter 3 Acute Myeloid Leukaemia: Integration of Morphological, Immunophenotypic and Genetic Information: the WHO and International Consensus Classifications -- Introduction -- The WHO classification of acute myeloid leukaemia -- Acute myeloid leukaemia with defining genetic abnormalities -- Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion -- Acute myeloid leukaemia with other RUNX1 rearrangement -- Acute promyelocytic leukaemia with PML::RARA fusion -- Acute myeloid leukaemia with t(11 -- 17)(q23.2 -- q21.2) -- ZBTB16::RARA or other RARA rearrangements -- Acute myeloid leukaemia with CBFB::MYH11 fusion -- Acute myeloid leukaemia with KMT2A rearrangement, particularly KMT2A::MLLT3 associated with t(9 -- 11) (p21.3 -- q23.3) -- Acute myeloid leukaemia with other KMT2A rearrangement -- Acute myeloid leukaemia with DEK::NUP214 fusion -- Acute myeloid leukaemia with MECOM rearrangement -- Acute myeloid leukaemia with other 3q21 or 3q26 rearrangements -- Acute myeloid leukaemia with RBM15::MRTFA fusion -- Acute myeloid leukaemia with BCR::ABL1 fusion -- Acute myeloid leukaemia with NPM1 mutation -- Acute myeloid leukaemia with CEBPA mutation -- Acute myeloid leukaemia with NUP98 rearrangement -- Acute myeloid leukaemia with RUNX1 mutation -- Acute myeloid leukaemia, myelodysplasia-related -- Acute myeloid leukaemia with other defined genetic alterations -- Acute myeloid leukaemia with KAT6A::CREBBP -- Acute myeloid leukaemia with FUS::ERG -- Acute myeloid leukaemia, defined by differentiation -- Acute myeloid leukaemia with minimal differentiation -- Acute myeloid leukaemia without maturation -- Acute myeloid leukaemia with maturation -- Acute basophilic leukaemia -- Acute myelomonocytic leukaemia -- Acute monocytic leukaemia -- Acute erythroid leukaemia -- Acute megakaryoblastic leukaemia -- Myeloid sarcoma |
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Acute myeloid leukaemia associated with antecedent and predisposing conditions -- Therapy-related acute myeloid leukaemia/acute myeloid leukaemia post cytotoxic therapy -- Acute myeloid leukaemia with germline predisposition -- Myeloid proliferation related to Down syndrome -- Transient abnormal myelopoiesis -- Acute myeloid leukaemia associated with Down syndrome -- The International Consensus Classification of acute myeloid leukaemia -- Other acute myeloid leukaemias and related conditions -- Acute myeloid leukaemia arising in a germ cell tumour with i(12p) -- Mast cell leukaemia -- Blastic plasmacytoid dendritic cell neoplasm -- Prognostic significance of cytogenetic and genetic abnormalities in acute myeloid leukaemia -- The role of immunophenotyping -- The diagnostic pathway -- Conclusions -- References -- Chapter 4 Acute Lymphoblastic Leukaemia and Acute Leukaemia of Mixed or Ambiguous Lineage -- Introduction -- The WHO classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of B lineage -- B lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities -- B lymphoblastic leukaemia/lymphoma with high hyperdiploidy -- B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion -- B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features -- B lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion -- B lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features -- B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement -- B lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion -- B lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion -- B lymphoblastic leukaemia/lymphoma with t(5 -- 14)(q31.1 -- q32.1) -- IGH::IL3 -- B lymphoblastic leukaemia/lymphoma with hypodiploidy -- B lymphoblastic leukaemia/lymphoma with iAMP21 -- B lymphoblastic leukaemia/lymphoma with other defined genetic alterations |
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B lymphoblastic leukaemia/lymphoma, not otherwise specified -- B lymphoblastic leukaemia/lymphoma in Down syndrome -- The International Consensus Classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of B lineage -- The WHO classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of T lineage -- T lymphoblastic leukaemia/lymphoma, not otherwise specified -- T lymphoblastic leukaemia/lymphoma with t(10 -- 14)(q24 -- q11.2) -- TLX1 dysregulation -- T lymphoblastic leukaemia/lymphoma with t(5 -- 14)(q35.1 -- q32.2) (cryptic) -- TLX3 dysregulation -- T lymphoblastic leukaemia/lymphoma with cryptic TALd deletion -- STIL::TAL1 -- T lymphoblastic leukaemia/lymphoma with NUP214::ABL1 fusion -- Early T-cell precursor lymphoblastic leukaemia/lymphoma -- The International Consensus Classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of T lineage -- Natural killer cell lymphoblastic leukaemia/lymphoma -- Therapy-related lymphoblastic leukaemia/lymphoma -- Acute leukaemias of mixed or ambiguous lineage -- Mixed phenotype acute leukaemias -- Mixed phenotype acute leukaemia with defined genetic abnormalities -- Mixed phenotype/ambiguous lineage acute leukaemia, defined by differentiation -- Mixed phenotype acute leukaemia, B/myeloid, not otherwise specified -- Mixed phenotype acute leukaemia, T/myeloid, not otherwise specified -- Mixed phenotype acute leukaemia, rare types -- Acute leukaemia of ambiguous lineage, not otherwise specified -- Acute undifferentiated leukaemia -- Conclusions -- References -- Chapter 5 The Myelodysplastic Syndromes, the Myelodysplastic/Myeloproliferative Neoplasms and Juvenile Myelomonocytic Leukaemia -- MYELODYSPLASTIC SYNDROMES/NEOPLASMS -- Recognition, nature and epidemiology -- Classification -- Cytochemistry -- Immunophenotyping -- Bone marrow trephine biopsy -- Cytogenetic features |
| Summary |
"The new edition of this practical reference on the principles of leukemia diagnosis and classification, now fully updated throughout and incorporates the recent 5th edition of the WHO classification. From the bestselling author, Barbara J. Bain, and the addition of Mike Leach for this 6th edition, this is a comprehensive, up-to-date volume that is extensively referenced, well-illustrated and authoritative. The book will build on the strengths of the previous editions and will serve both those who are relatively new to the field and more experienced practitioners who will be able to use it as a convenient reference source. Specifically, it explains the application of the latest (5th edition) WHO classification of leukaemias and the relationship of this classification to the newly developed International Consensus Classification. This book will be fully updated throughout and include recent developments and the growing importance of molecular genetics. Leukaemias are a very heterogeneous group of diseases, which differ from each other in aetiology, pathogenesis, prognosis and responsiveness to treatment. Accurate diagnosis and classification are vital for the identification of specific biological entities and underpin scientific advances in this field. The detailed characterization of haematological neoplasms is also essential for the optimal management of individual patients"-- Provided by publisher |
| Notes |
Molecular genetic features |
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Description based on publisher supplied metadata and other sources |
| Subject |
Immunophenotyping.
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Leukemia -- classification
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Leukemia -- diagnosis
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Immunophenotyping
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Cytogenetic Analysis
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| Form |
Electronic book
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| Author |
Leach, Mike
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| ISBN |
1394218605 |
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9781394218608 |
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1394218613 |
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9781394218615 |
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1394218591 |
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9781394218592 |
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