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Title Cytochromes P450 : role in the metabolism and toxicity of drugs and other xenobiotics / edited by Costas Ioannides
Published Cambridge : RSC Pub., ©2008


Description 1 online resource (xviii, 521 pages) : illustrations
Series Issues in toxicology
Issues in toxicology.
Contents Cytochrome P450 structure and function : an evolutionary perspective / David F.V. Lewis and Yuko Ito -- Generation of reactive intermediates by Cytochromes P450 / Hermann M. Bolt and Peter H. Roos -- The CYP1A subfamily / Bhagavatula Moorthy -- The CYP1B subfamily / Morag C.E. McFadyen and Graeme I. Murray -- The CYP2A subfamily / Hannu Raunio, Jukka Hakkola, and Olavi Pelkonen -- The CYP2B subfamily / Laurent Corcos and François Berthou -- The CYP2C subfamily / Stephen S. Ferguson, Karen Black and Jonathan P. Jackson -- The CYP2D subfamily / Ulrich M. Zanger -- The CYP2E subfamily / Lowell C. Overton, Alice Hudder and Raymond F. Novak -- The CYP2F, CYP2G and CYP2J subfamilies / Qing-Yu Zhang and Xinxin Ding -- The CYP3 family / David J. Greenblatt, Ping He, Lisa L. von Moltke, and Michael H. Court -- The CYP4 family / Allan E. Rettie and Edward J. Kelly / Receptor-mediated regulation of Cytochromes P450 / Kouichi Yoshinari, Eric Tien, Masahiko Negishi and Paavo Honkakoski -- Modulation of Cytochromes P450 by phytochemicals / Michael Murray -- Cytochromes P450 in cancer therapeutics / Thomas K.H. Chang
Summary During half a century, cytochrome P450 in its original uniqueness as an optically ""wrong"" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme s
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cytochrome P-450 -- Metabolism
Cytochrome P-450 -- Toxicology
Xenobiotics -- Metabolism
Cytochrome P-450 Enzyme System -- physiology [mesh]
Cytochrome P-450 Enzyme System -- metabolism [mesh]
Drug Toxicity [MESH]
Pharmaceutical Preparations -- metabolism [mesh]
SCIENCE -- Life Sciences -- Biochemistry.
Cytochrome P-450 -- Metabolism
Xenobiotics -- Metabolism
Form Electronic book
Author Ioannides, Costas.
ISBN 9781847558428