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Book Cover
E-book

Title Cytochrome P450 function and pharmacological roles in inflammation and cancer / edited by James P. Hardwick
Published Waltham, MA : Academic Press, 2015

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Description 1 online resource
Series Advances in pharmacology ; volume 74
Advances in pharmacology (San Diego, Calif.) ; 74.
Contents Front Cover; Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer; Copyright; Contents; Contributors; Preface; References; Chapter One: Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism; 1. Introduction; 2. Historical Aspects of Chemical Carcinogenesis Leading to Discovery of the Cytochrome P450 Monooxygenase; 2.1. Cytochromes P450; 2.2. Butter Yellow Carcinogenesis; 2.3. PAH Carcinogenesis: Protein Adducts and Induction of Metabolism
3. Cytochrome P450-Monooxygenase-Mediated Activation of Procarcinogen and Chemotherapeutic Prodrugs3.1. Aromatic Azo Compounds; 3.2. Polycyclic Aromatic Hydrocarbons; 3.3. Polychlorinated Biphenyls; 3.3.1. Polychlorinated Biphenyls with Low Chlorine Content; 3.3.2. Highly Chlorinated Biphenyls; 3.4. Vinyl Chloride; 3.5. Nitrosamines; 3.6. Furans; 3.7. Chemotherapeutic Prodrugs; 3.7.1. Cyclophosphamide; 3.7.2. Procarbazine and Other Hydrazine Derivatives; 3.7.3. Anthracycline Antibiotics; 4. Factors That Regulate Changes in Gene Expression: Differences Between Rodents and Humans
4.1. Hepatic Nuclear Receptors and Enzyme Induction4.2. Differences Between Rodent and Human Receptors; 4.3. CAR Splice Variants and Ligand Specificity; 4.4. Exogenous Compounds Acting on the PPAR; 4.5. Underlying Regulation by Other Hormones and Transcription Factors; 4.6. Effects of Environmental Agents; 5. Polymorphic Cytochrome P450 Variants Impacting Expression and Cancer Susceptibility; 5.1. Cytochrome P4501A1 and Glutathione S-Transferase M1; 5.2. Cytochrome P4502D6 and Cytochrome P4502E1; 6. Conclusion; Conflict of Interest; Acknowledgment; References
Chapter Two: Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer1. Introduction; 2. Reactive Oxygen Species Formation in Biological Systems; 2.1. Oxygen Reactivity and Formation of Reactive Oxygen Species; 2.2. Types of Reactive Oxygen Species and Their Reactivities; 2.2.1. Superoxide Radical Anion; 2.2.2. Hydrogen Peroxide; 2.2.3. Hydroxyl Radical; 2.2.4. Peroxyl Radical; 2.2.5. Singlet Oxygen; 3. Protective Agents to Combat Reactive Oxygen Species; 3.1. Antioxidants; 3.1.1. Antioxidant Enzymes; 3.1.2. Nonenzymatic Antioxidants; 3.1.2.1. Glutathione
Summary Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer. <ul><li>Contains contributions from the best authors in the field</li><li>Ideal reference for those conducting research in cancer, inflammation, cytochrome P450, metabolism, liver disease, and oxidative stress</li><li>Provides an essential resource for pharmacologists, immunologists, and biochemists</li></ul>
Bibliography Includes bibliographical references and index
Notes Online resource; title from title details screen (ScienceDirect, viewed August 6, 2015)
Subject Cytochrome P-450.
Cytochrome P-450 -- Physiological effect
Cytochrome P-450 -- Therapeutic use
Monooxygenases -- Therapeutic use
Monooxygenases -- Physiological effect
Inflammation -- Pathophysiology
Cancer -- Pathophysiology.
Inflammation -- Treatment
Cancer -- Treatment.
Cytochrome P-450 Enzyme System
SCIENCE -- Life Sciences -- Biochemistry.
Cancer -- Pathophysiology.
Cancer -- Treatment.
Cytochrome P-450
Cytochrome P-450 -- Physiological effect.
Inflammation -- Pathophysiology.
Form Electronic book
Author Hardwick, James P., editor
ISBN 9780128031209
0128031204