Title Mitochondrial oxidative phosphorylation : nuclear-encoded genes, enzyme regulation, and pathophysiology / edited by Bernhard Kadenbach

Published New York ; London : Springer, 2012

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Description 1 online resource : illustrations (some color) Series Advances in experimental medicine and biology ; 748 Advances in experimental medicine and biology ; 748. Contents Introduction to Mitochondrial Oxidative Phosphorylation / Bernhard Kadenbach -- Mitochondrial Dynamics: The Intersection of Form and Function / Andrew Ferree and Orian Shirihai -- Biogenesis of Mitochondrial Proteins / Johannes M. Herrmann, Sebastian Longen, Daniel Weckbecker and Matthieu Depuydt -- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology / Daniele Ghezzi and Massimo Zeviani -- Supramolecular Organisation of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation / Giorgio Lenaz and Maria Luisa Genova -- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain / Stefan Dröse and Ulrich Brandt -- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins / Richard K. Porter -- Evolution of the Couple Cytochrome c and Cytochrome c Oxidase in Primates / Denis Pierron, Derek E. Wildman, Maik Hüttemann, Thierry Letellier and Lawrence I. Grossman -- Reaction Mechanism of Mammalian Mitochondrial Cytochrome c Oxidase / Shinya Yoshikawa, Kazumasa Muramoto and Kyoko Shinzawa-Itoh -- Phosphorylation of Mammalian Cytochrome c and Cytochrome c Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease / Maik Hüttemann, Icksoo Lee, Lawrence I. Grossman, Jeffrey W. Doan and Thomas H. Sanderson -- Individual Biochemical Behaviour Versus Biological Robustness: Spotlight on the Regulation of Cytochrome c Oxidase / Rabia Ramzan, Petra Weber, Bernhard Kadenbach and Sebastian Vogt -- Bigenomic Regulation of Cytochrome c Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism / Margaret T.T. Wong-Riley -- Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection / Susanne Arnold -- The Many Clinical Faces of Cytochrome c Oxidase Deficiency / Salvatore DiMauro, Kurenai Tanji and Eric A. Schon Summary This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered Analysis celbiologie cellular biology biomedische wetenschappen biomedicine genexpressie gene expression humane genetica human genetics Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes English Print version record Subject Mitochondrial DNA. Mitochondrial pathology. Eukaryotic cells. Cytochrome c. Multienzyme complexes Phosphorylation. Metabolism. Energy metabolism. Cell organelles. Cytochromes. Enzymes. Hemoproteins. Cytoplasm. Cells. Proteins. Anatomy. Mitochondria. Cytochrome c Group Subcellular Fractions Multienzyme Complexes Phosphorylation Metabolism Energy Metabolism Organelles Phenomena and Processes Cytoplasmic Structures Biochemical Phenomena Cytochromes Cellular Structures Enzymes Chemical Phenomena Hemeproteins Enzymes and Coenzymes Cytoplasm Cells Proteins Chemicals and Drugs Intracellular Space Anatomy Amino Acids, Peptides, and Proteins Oxidative Phosphorylation Electron Transport Chain Complex Proteins Mitochondria Cytochromes c DNA, Mitochondrial Eukaryotic Cells Animal Structures metabolism (biological concept) enzyme. hemoprotein. protein. anatomy. SCIENCE -- Life Sciences -- Genetics & Genomics. Proteins Phosphorylation Multienzyme complexes Mitochondria Metabolism Hemoproteins Enzymes Energy metabolism Cytoplasm Cytochromes Cytochrome c Cells Cell organelles Anatomy Eukaryotic cells Mitochondrial DNA Mitochondrial pathology Form Electronic book Author Kadenbach, Bernhard ISBN 9781461435730 1461435730 1493901567 9781493901562

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