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Title Cytochrome P450 : structure, mechanism, and biochemistry / edited by Paul R. Ortiz de Montellano
Edition 3rd ed
Published New York : Kluwer Academic/Plenum Publishers, ©2005


Description 1 online resource (xx, 689 pages) : illustrations
Contents Models and mechanisms of Cytochrome P450 action / John T. Groves -- Computational approaches to Cytochrome P450 function / Sason Shaik and Samuël De Visser -- Structures of Cytochrome P450 enzymes / Thomas Poulos and Eric Johnson -- Electron transfer partners of Cytochrome P450 / Mark Paine, Nigel Scrutton, Andrew Munro, Aldo Gutierrez, Gordon Roberts and C. Wolf -- Activation of molecular oxygen by Cytochrome P450 / Thomas Makris, Ilia Denisov, Ilme Schlichting and Stephen Sligar -- Substrate oxidation by Cytochrome P450 enzymes / Paul Ortiz de Montellano and James De Voss -- Inhibition of Cytochrome P450 enzymes / Maria Correia and Paul Ortiz de Montellano -- Induction of Cytochrome P450 enzymes / Susanne Williams, Elizabeth Dunham and Christopher Bradfield -- Hormonal regulation of liver Cytochrome P450 enzymes / David J. Waxman and Thomas K.H. Chang -- Human Cytochrome P450 enzymes / F. Guengerich -- Cytochrome P450 and the metabolism and bioactivation of arachidonic acid and eicosanoids / Jorge Capdevila, Vijaykumar Holla and John Falck -- Cytochrome P450s in plants / Kirsten Nielsen and Birger Møller -- The diversity and importance of microbial Cytochromes P450 / Steven Kelly, Diane Kelly, Colin Jackson, Andrew Warrilow and David Lamb
Summary Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years
Bibliography Includes bibliographical references and index
Notes English
In Springer e-books
Subject Cytochrome P-450.
Amino acid sequence.
Cytochrome P-450 Enzyme System -- chemistry
Cytochrome P-450 Enzyme System -- physiology
Amino Acid Sequence
Molecular Sequence Data
Cytochrome P-450 Enzyme System
Amino acid sequence
Cytochrome P-450
Form Electronic book
Author Ortiz de Montellano, Paul R.
LC no. 2004043512
ISBN 0306483246