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Title Cytochrome P450 2E1 : its role in disease and drug metabolism / Aparajita Dey, editor
Published Dordrecht : Springer, ©2013


Description 1 online resource (267 pages)
Series Subcellular biochemistry, 0306-0225 ; v. 67
Sub-cellular biochemistry ; v. 67.
Contents Cytochrome P450 2E1: Its Clinical Aspects and a Brief Perspective on the Current Research Scenario / Aparajita Dey -- Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity / Arthur I. Cederbaum -- The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis / Helmut K. Seitz, Xiang-Dong Wang -- The Importance of CYP2E1 in the Pathogenesis of Alcaoholic Liver Disease and Drug Toxicity and the Role of the Proteasome / Samuel W. French -- Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease / Ann K. Daly -- CYP2E1-Catalyzed Alcohol Metabolism: Role of Oxidant Generation in Interferon Signaling, Antigen Presentation and Autophagy / Natalia A. Osna, Terrence M. Donohue Jr. -- CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism / M. Raj Lakshman, Mamatha Garige -- The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System / Claire Heit, Hongbin Dong, Ying Chen
Summary The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Cytochrome P-450 CYP2E1 -- Toxicology
Cytochrome P-450 CYP2E1 -- Metabolism
Fatty liver -- Pathophysiology
Cytochrome P-450 CYP2E1.
Fatty Liver -- physiopathology
Cytochrome P-450 CYP2E1 -- metabolism
Cytochrome P-450 CYP2E1 -- toxicity
Cytochrome P-450 CYP2E1
SCIENCE -- Life Sciences -- Biochemistry.
Cytochrome P-450 CYP2E1
Form Electronic book
Author Dey, Aparajita
ISBN 9789400758810