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Book Cover
E-book
Author Baumann, Pierre

Title CYP2D6
Published London : Future Science Group, 2014

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Description 1 online resource (159 pages)
Contents CYP2D6: genetics, pharmacology and clinical relevance -- A history and overview of phenotypic variability in CYP2D6 activity -- Genetic variability of CYP2D6: basic and clinical aspects -- CYP2D6: interethnic variability -- CYP2D6 ethnic variability in Hispanics -- Structural properties of CYP2D6: requirements for substrates and inhibitors -- CYP2D6 substrates and drug metabolism -- _GoBack -- _ENREF_1 -- _ENREF_2 -- _ENREF_3 -- _ENREF_4 -- _GoBack -- _ENREF_1 -- _ENREF_2 -- _ENREF_3 -- _ENREF_4 -- _ENREF_5 -- _ENREF_6 -- _ENREF_7 -- _ENREF_8
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OLE_LINK3OLE_LINK2 -- OLE_LINK1 -- OLE_LINK28 -- OLE_LINK27 -- OLE_LINK30 -- OLE_LINK29 -- OLE_LINK32 -- OLE_LINK31 -- OLE_LINK34 -- OLE_LINK33 -- OLE_LINK36 -- OLE_LINK35 -- OLE_LINK38 -- OLE_LINK37 -- OLE_LINK24 -- OLE_LINK23 -- OLE_LINK40 -- OLE_LINK39 -- OLE_LINK42 -- OLE_LINK41 -- OLE_LINK44 -- OLE_LINK43 -- OLE_LINK46 -- OLE_LINK45 -- OLE_LINK48 -- OLE_LINK47 -- _GoBack -- OLE_LINK9 -- OLE_LINK8 -- OLE_LINK7 -- OLE_LINK13 -- OLE_LINK12 -- OLE_LINK22 -- OLE_LINK15 -- OLE_LINK14 -- OLE_LINK11 -- OLE_LINK10
OLE_LINK17OLE_LINK16 -- OLE_LINK19 -- OLE_LINK18 -- _GoBack -- OLE_LINK2 -- OLE_LINK3 -- Molecular mechanism of CYP2D6-mediated oxidation -- Substrate binding to CYP2D6 active site -- CYP2D6 substrates that are commercially available drugs -- Implications of variability in exposure to CYP2D6 substrates -- Modeling of CYP2D6 genotype-related variability in the pharmacokinetics of CYP2D6 substrates -- Assessment of CYP2D6-mediated elimination in the early stages of drug development -- _GoBack -- _GoBack -- _ENREF_1 -- _ENREF_2 -- _ENREF_3 -- _ENREF_4
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Summary In this book of nine chapters, expert authors explore the properties of CYP2D6 with respect to the basic genetic aspects, its interactions with drugs that are substrates and/or inhibitors, and the implications of the pharmacogenetics of CYP2D6 in the clinical context
Bibliography Includes bibliographical references at the end of each chapters and index
Notes Print version record
Subject Cytochrome P-450 -- Physiological effect
Cytochrome P-450 -- Genetics
Cytochrome P-450 -- Therapeutic use
Cytochrome P-450 -- Physiological effect.
Form Electronic book
ISBN 9781780844633
1780844638