| Description |
1 online resource : illustrations |
| Series |
Subcellular biochemistry, 0306-0225 ; 62 |
|
Sub-cellular biochemistry ; 62.
|
| Contents |
Composition and Dynamics of the Eukaryotic Replisome: A Brief Overview / Stuart MacNeill -- Evolutionary Diversification of Eukaryotic DNA Replication Machinery / Stephen J. Aves, Yuan Liu and Thomas A. Richards -- The Origin Recognition Complex: A Biochemical and Structural View / Huilin Li and Bruce Stillman -- Archaeal Orc1/Cdc6 Proteins / Stephen D. Bell -- Cdt1 and Geminin in DNA Replication Initiation / Christophe Caillat and Anastassis Perrakis -- MCM Structure and Mechanics: What We Have Learned from Archaeal MCM / Ian M. Slaymaker and Xiaojiang S. Chen -- The Eukaryotic Mcm2-7 Replicative Helicase / Sriram Vijayraghavan and Anthony Schwacha -- The GINS Complex: Structure and Function / Katsuhiko Kamada -- The Pol [alpha]-Primase Complex / Luca Pellegrini -- The Structure and Function of Replication Protein A in DNA Replication / Aishwarya Prakash and Gloria E.O. Borgstahl -- Structural Biology of Replication Initiation Factor Mcm10 / Wenyue Du, Melissa E. Stauffer and Brandt F. Eichman -- Structure and Function of Eukaryotic DNA Polymerase [delta] / Tahir H. Tahirov -- DNA Polymerase [epsilon] / Matthew Hogg and Erik Johansson -- The RFC Clamp Loader: Structure and Function / Nina Y. Yao and Mike O'Donnell -- PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA / Lynne M. Dieckman, Bret D. Freudenthal and M. Todd Washington -- The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation / L. David Finger, John M. Atack, Susan Tsutakawa, Scott Classen and John Tainer, et al. -- DNA Ligase I, the Replicative DNA Ligase / Timothy R.L. Howes and Alan E. Tomkinson |
| Summary |
High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and ins |
| Analysis |
Oncology |
|
Biochemistry |
|
Nucleic acids |
|
Biomedicine |
|
Protein Science |
|
Protein Structure |
|
eiwitten |
|
proteins |
|
biomedische wetenschappen |
|
biochemie |
|
neoplasms |
|
chemie |
|
chemistry |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| Subject |
Eukaryotic cells.
|
|
Chromosome replication.
|
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DNA replication.
|
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Chemicals and Drugs
|
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Chemical Phenomena
|
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Phenomena and Processes
|
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Multiprotein Complexes
|
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DNA Replication
|
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Biochemical Phenomena
|
|
Macromolecular Substances
|
|
Genetic Phenomena
|
|
Eukaryotic Cells
|
|
SCIENCE -- Life Sciences -- Cell Biology.
|
|
DNA replication
|
|
Chromosome replication
|
|
Eukaryotic cells
|
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Complexes multiprotéiques.
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Chromosomes -- Réplication.
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ADN -- Réplication.
|
| Form |
Electronic book
|
| Author |
MacNeill, Stuart
|
| ISBN |
9789400745728 |
|
9400745729 |
|
9400745710 |
|
9789400745711 |
|
9400797702 |
|
9789400797703 |
|
