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Title Nanotechnology in diagnosis, treatment and prophylaxis of infectious diseases / edited by Mahendra Rai, Kateryna Kon
Published London : Academic Press is an imprint of Elsevier, [2015]
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Description 1 online resource : illustrations (some color)
Contents Front Cover; Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases; Copyright Page; Contents; List of Contributors; Preface; 1 Gold and Silver Nanoparticles for Diagnostics of Infection; 1.1 Nanotechnology and Infection; 1.2 Gold and Silver NPs for Molecular Diagnostics; 1.2.1 Biomarkers; 1.3 Nanodiagnostics for Nucleic Acids; 1.3.1 Homogeneous Colorimetric Assays; 1.3.1.1 Unmodified NPs; 1.3.1.2 Cross-Linking; 1.3.1.3 Noncross-Linking; 1.3.2 Heterogeneous Detection; 1.3.2.1 Microarrays; 1.3.2.2 Lateral Flow Assays; 1.3.3 Electrochemical Assays
1.3.4 Fluorescence Assays1.3.5 Raman and SERS; 1.3.6 Other; 1.4 Aptamers and Antibodies; 1.4.1 Colorimetric; 1.4.2 Electrochemical; 1.4.3 Lateral Flow Assays; 1.5 iPCR and Other Methods; 1.6 Conclusion; References; 2 Antimicrobial Models in Nanotechnology: From the Selection to Application in the Control and Treatment of Infectious Diseases; 2.1 Introduction; 2.2 Antimicrobial Susceptibility Testing Methods of NMs; 2.2.1 Broth Dilution Test; 2.2.2 Spectrophotometric Measurement; 2.2.3 Cell Counting; 2.2.4 Colorimetric and Fluorescent Assays; 2.2.5 In Vitro Infection Animal Model
2.2.6 Biocidal Testing2.2.7 Antibiofilm Activity; 2.2.8 Quorum-Sensing Inhibitors; 2.2.9 Microbial Membrane Lysis; 2.2.10 Microbial Oxidative Stress; 2.2.11 Antipersister and Antidormancy Bacterial Cells; 2.2.12 Microbial Fitness; 2.3 Nanotoxicology; 2.3.1 Nano-Genotoxicology; 2.3.2 Cytotoxicity; 2.3.3 Immunotoxicity; 2.3.4 In Vitro Skin Irritation; 2.3.5 Caenorhabditis elegans Toxicity Model; 2.3.6 Nanotoxicity in Embryonic and Adult Zebrafish; 2.3.7 Bioluminescence-Based Nanotoxicity Test; 2.4 In Vitro Pharmacokinetics/Pharmacodynamic Models; 2.4.1 Particokinetics; 2.4.2 Caco-2 Permeability
2.4.3 Hollow Fiber System2.5 Conclusions; References; 3 Silver Nanoparticles for the Control of Vector-Borne Infections; 3.1 Introduction; 3.2 Louse-Borne Infections and Activity of AgNPs Against Lice; 3.3 Mosquito-Borne Infections and Activity of AgNPs Against Mosquitoes; 3.4 Tick-Borne Infections and Activity of AgNPs Against Ticks; 3.5 Flies, Their Role in Transmission and Spread of Infections, and Activity of AgNPs Against Flies; 3.6 Conclusions and Future Prospects; References; 4 Magnetite Nanostructures: Trends in Anti-Infectious Therapy; 4.1 Introduction
4.2 Nanoparticles with Biomedical Applications4.2.1 Design of Tailored Magnetic Nanoparticles with Applications in Microbiology; 4.2.2 Magnetite Nanoparticles Used to Control Microorganisms Attachment and Biofilm Formation; 4.2.3 The Biocompatibility of Magnetite Nanoparticles; 4.2.3.1 Biocompatibility Evaluation of Magnetite Nanoparticles at the Cellular Level; 4.2.3.2 Biocompatibility Evaluation of Magnetite Nanoparticles at Biochemical and Molecular Level; 4.2.3.3 Biocompatibility Evaluation of Magnetite Nanoparticles Using Animal Models; 4.3 Conclusions; References
Summary Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases delivers comprehensive coverage of the application of nanotechnology to pressing problems in infectious disease. This text equips readers with cutting-edge knowledge of promising developments and future prospects in nanotechnology, paying special attention to microbes that are now resistant to conventional antibiotics, a concerning problem in modern medicine. Readers will find a thorough discussion of this new approach to infectious disease treatment, including the reasons nanotechnology presents a promising avenue for the diagnosis, treatment, and prophylaxis of infectious diseases. Provides a comprehensive overview of the use of nanotechnology in the treatment and diagnosis of infectious diseasesCovers all common types of infective agents, including bacteria, viruses, fungi, and protozoa, along with their vectors, ticks, mosquitoes, flies, etc. Delivers commentary from an international researcher base, providing insights across differing economic statusesIncludes a foundation of basic nanotechnological concepts to aid in designing new strategies to combat several pathogenic diseases and cancerIllustrates the high antimicrobial potential of nanoparticles, ultimately demonstrating how they are a promising alternative class that can be successfully used in fighting a myriad of infections
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (Ebsco, viewed May 29, 2015)
Subject Communicable diseases -- Diagnosis -- Technological innovations.
Communicable diseases -- Treatment -- Technological innovations.
Nanomedicine.
Communicable Diseases.
Form Electronic book
Author Kon, Kateryna Volodymyrivna, editor
Rai, Mahendra, editor
ISBN 0128014717 (electronic bk.)
9780128014714 (electronic bk.)