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Author Observational Studies in a Learning Health System (Workshop) (2013 : Washington, D.C.)

Title Observational studies in a learning health system : workshop summary / Claudia Grossmann and Joe Alper, rapporteurs ; a Learning Health System Activity, Roundtable on Value & Science-Driven Health Care, Institute of Medicine of the National Academies
Published Washington, D.C. : The National Academies Press, [2013]

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Description 1 online resource (xix, 114 pages) : illustrations (chiefly color
Series Online access: NCBI NCBI Bookshelf
Contents Introduction -- Issues overview for observational studies in clinical research -- Engaging the issue of bias -- Generalizing randomized clinical trial results to broader populations -- Detecting treatment-effect heterogeneity -- Predicting individual responses -- Strategies going forward -- Common themes for progress
Summary "Clinical research strains to keep up with the rapid and iterative evolution of medical interventions, clinical practice innovation, and the increasing demand for information on the clinical effectiveness of these advancements. In response to the growing availability of archived and real-time digital health data and the opportunities this data provides for research, as well as the increasing number of studies using prospectively collected clinical data, the Institute of Medicine's Roundtable on Value & Science-Driven Health Care convened a workshop on Observational Studies in a Learning Health System. Participants, including experts from a wide range of disciplines - clinical researchers, statisticians, biostatisticians, epidemiologists, health care informaticians, health care analytics, research funders, health products industry, clinicians, payers, and regulators - explored leading edge approaches to observational studies, charted a course for the use of the growing health data utility, and identified opportunities to advance progress. Workshop speakers and individual participants strove to identify stakeholder needs and barriers to the broader application of observational studies. Observational Studies in a Learning Health System is the summary of the workshop. This report explores the role of observational studies in the generation of evidence to guide clinical and health policy decisions. The report discusses concepts of rigorous observational study design and analysis, emerging statistical methods, and opportunities and challenges of observational studies to complement evidence from experimental methods, treatment heterogeneity, and effectiveness estimates tailored toward individual patients"--Publisher's description
Notes "Observational Studies in a Learning Health System: an Institute of Medicine workshop, sponsored by the Patient-Centered Outcomes Research Institute; a Learning Health System Activity, IOM Roundtable on Value & Science-Driven Health Care, April 25-26, 2013, National Academy of Sciences"--Page 101
Bibliography Includes bibliographical references
Notes English
Print version record
Subject Clinical medicine -- Research -- Congresses
Experimental design -- Congresses
Evidence-based medicine -- Congresses
Medical care -- Congresses
Statistics -- Methodology
Observational Studies as Topic -- methods
Research Design -- standards
Prospective Studies
Data Collection
Delivery of Health Care -- methods
Evidence-Based Medicine -- methods
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Clinical medicine -- Research
Evidence-based medicine
Experimental design
Medical care
Genre/Form Conference papers and proceedings
Form Electronic book
Author Grossmann, Claudia, 1978- author.
Alper, Joe, author
Institute of Medicine (U.S.). Roundtable on Value & Science-Driven Health Care, issuing body.
Patient-Centered Outcomes Research Institute (U.S.), sponsoring body.
ISBN 9780309290821
0309290821
0309290848
9780309290845