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Book Cover
E-book
Author International Conference on New Strategies for the Treatment of Liver Cirrhosis (2001 : Tokyo, Japan)

Title Extracellular matrix and the liver : approach to gene therapy / edited by Isao Okazaki [and others]
Published Amsterdam ; Boston : Academic Press, ©2003

Copies

Description 1 online resource (xxi, 467 pages) : illustrations
Contents New Insights into the Extracellular Matrix. -- Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors. -- Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates. -- Functions of Proteoglycan/Glycosaminoglycan in Liver; SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology. -- Cells Responsible for ECM Production in the Liver. Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential. -- Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair. -- Molecular Mechanism of Stellate Cell Activation and ECM Remodeling. -- Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype. Knockout Mice of Matrix Metalloproteinase Genes. Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis
Summary Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology
Analysis matrixeiwitten
matrix proteins
metalloproteins
metalloproteinases
remmers
inhibitors
gentherapie
gene therapy
behandeling
treatment
cirrose
cirrhosis
leverziekten
liver diseases
lever
liver
Human Pathology
Humane pathologie
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Liver -- Cirrhosis -- Treatment
Liver -- Cirrhosis -- Gene therapy
Extracellular matrix.
Liver Cirrhosis -- pathology
Extracellular Matrix
Extracellular Matrix -- genetics
Liver Cirrhosis -- therapy
Extracellular matrix
Liver -- Cirrhosis -- Treatment
Genre/Form proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Okazaki, Isao
ISBN 9780125252515
012525251X
1281037729
9781281037725
9786611037727
6611037721
0080531504
9780080531502