| Description |
1 online resource (xv, 451 pages) : illustrations (some color) |
| Series |
Molecular and integrative toxicology |
|
Molecular and integrative toxicology.
|
| Contents |
Part 1. INTRODUCTION -- Introduction to Immunotoxicity / Keith D. Salazar and Rosana Schafer -- The Environment-Immune Route to Chronic Disease / Rodney R. Dietert and Robert W. Luebke -- Part 2. ALLERGIC DISEASES -- Asthma and Respiratory Allergic Disease / David M. Lehmann and Marc A. Williams -- Cutaneous Allergies / David A. Basketter and John P. McFadden -- Food Allergies / Christal C. Bowman -- Part 3. AUTOIMMUNE AND INFLAMMATORY DISEASES AND CONDITIONS -- Factors Involved in Onset of Type 1 Diabetes / Anne Cooke and Paola Zaccone -- Rheumatoid Arthritis / Jean C. Pfau -- Environment, Immune Dysfunction, and Systemic Lupus Erythematosus / Moran Landau Rabbi, Ilan Ben-Zvi, Nancy Agmon-Levin and Yehuda Shoenfeld -- Multiple Sclerosis, Alzheimer's Disease, and Inflammation: A Hypothetical View / Margaret S. Bynoe and Christophe Viret -- Immune Dysfunction in Autism Spectrum Disorders / Milo Careaga, Judy Van de Water and Paul Ashwood -- Atherosclerosis and Inflammatory Heart Disease / DeLisa Fairweather -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences / Rodney R. Dietert -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR Signaling / Celine A. Beamer, Benjamin P. Seaver and David M. Shepherd -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis / Midori Tanaka, Sherry Anders and Dennis K. Kinney -- Part 4. INFECTIONS AND CANCER -- Environmental Toxicants and Susceptibility to Infection / Carsten Heilmann -- Childhood Acute Leukemia / Joseph Wiemels -- Part 5. PREVENTION OF CHRONIC DISEASES -- Reducing the Prevalence of Immune-Based Chronic Disease / Rodney R. Dietert, Jamie C. DeWitt and Robert W. Luebke |
| Summary |
Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes, multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus.¡ Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction.¡ Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions.¡ This¡volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.¡ ¡ |
| Analysis |
Medicine |
|
Immunology |
|
Toxicology |
|
Biomedicine |
|
Pharmacology/Toxicology |
|
Molecular Medicine |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Chronic diseases -- Immunological aspects
|
|
Immunotoxicology.
|
|
Chronic diseases.
|
|
Immunologic diseases.
|
|
Chronic Disease
|
|
Immune System Diseases
|
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Immunotoxins -- adverse effects
|
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MEDICAL -- Long-Term Care.
|
|
Immunologic diseases
|
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Chronic diseases
|
|
Immunotoxicology
|
| Form |
Electronic book
|
| Author |
Dietert, Rodney R.
|
|
Luebke, Robert W.
|
| ISBN |
9781617798122 |
|
1617798126 |
|
9781280786723 |
|
1280786728 |
|
1627039260 |
|
9781627039260 |
|
