| Description |
1 online resource (lxiv, 774 pages) : illustrations |
| Contents |
Front Cover -- Cholinergic Mechanisms: Function and Dysfunction -- Copyright Page -- Contents -- Preface -- List of contributors -- Platform presentations -- Edith Heilbronn Lecture -- 1. In memoriam: Edith Heilbronn -- Nicotinic receptors: structure -- 2. Nicotinic acetylcholine receptors: probing functionally significant structural changes with site-directed reactions -- 3. The binding site for Î"-bungarotoxin in the acetylcholine receptor: from synthetic peptides to solution and crystal structure |
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4. Pharmacological and structural characterization of the interaction of snake toxins with nicotinic acetylcholine receptors5. Structure and dynamics of acetylcholine receptor and its lipid microenvironment: from molecule to cell -- 6. Site-directed reactive probes for structural and functional investigation of cholinergic proteins -- 7. The mechanism for acetylcholine receptor inhibition by Î"-neurotoxins and species-specific resistance to Î" -bungarotoxin revealed by NMR -- Muscarinic receptors: structure -- 8. Structure and activation of muscarinic acetylcholine receptors |
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9. Generation and analysis of muscarinic acetylcholine receptor knockout mice10. Roles of external loops of muscarinic receptors in interactions between N-methylscopolamine and allosteric modulators -- Couteaux lecture -- 11. Rene Couteaux (1909�1999) and his presynaptic active zone -- 12. René Couteaux Lecture: Ligand recognition in the cholinergic nervous system analysed by structural templates and protein dynamics -- Presynaptic mechanisms -- 13. Neuronal calcium dynamics: one message with many meanings |
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14. Acetylcholine- and glutamate-mediated transmission: one mediatophore with different specificities, or several mediatophores?15. The Ca-voltage hypothesis for neurotransmitter release � current status -- Structural and regulatory aspects of the cholinergic synapse -- 16. The role of P2Y1 nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junctions -- 17. Control of expression of nicotinic receptor and acetylcholinesterase in the developing neuromuscular junction in the human muscle |
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18. The molecular neurobiology of acetylcholinesterase variants: from stressful insults to antisense intervention19. Transcriptional control of the cholinergic gene locus: a mosaic model for regulation of the cholinergic phenotype -- 20. Regulation of cholinergic gene expression by NRSF/REST -- 21. Unveiling the molecular events leading to a neurotransmitter phenotype switch in developing neurons -- Miriam Salpeter Lecture -- 22. Miriam M Salpeter (Mika) � biographical notes -- 23. Chemical kinetics parameters and receptor degradation rates at the neuromuscular junction |
| Summary |
The triennnial symposium on cholinergic mechanisms provides a key multidisciplinary forum for their interaction, and the proceedings of the XIth ISCM provide a cutting edge profile of research progress in this important field of research |
| Notes |
"A Martin Dunitz Book." |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Cholinergic mechanisms -- Congresses
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Alzheimer's disease -- Congresses
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Autoimmune diseases -- Congresses
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Alzheimer's disease.
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Autoimmune diseases.
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Receptors, Cholinergic -- physiology
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Alzheimer Disease
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Autoimmune Diseases
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Synaptic Transmission -- physiology
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MEDICAL -- Neuroscience.
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PSYCHOLOGY -- Neuropsychology.
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Alzheimer's disease
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Autoimmune diseases
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Cholinergic mechanisms
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| Genre/Form |
proceedings (reports)
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Conference papers and proceedings
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Conference papers and proceedings.
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Actes de congrès.
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| Form |
Electronic book
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| Author |
Silman, Israel.
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| ISBN |
0203493877 |
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9780203493878 |
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1280241047 |
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9781280241048 |
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9781135417505 |
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1135417504 |
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9781135417451 |
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1135417458 |
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9781135417499 |
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1135417490 |
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