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Book Cover
E-book
Author Chemicals, Panel on Anticholinesterase

Title Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents
Published Washington : National Academies Press, 1981

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Description 1 online resource (298 pages)
Contents ""POSSIBLE LONG-TERM HEALTH EFFECTS OF SHORT-TERM EXPOSURE TO CHEMICAL AGENTS""; ""Copyright""; ""ACKNOWLEDGEMENTS""; ""PREFACE""; ""EXECUTIVE SUMMARY""; ""ANTICHOLINESTERASE CHEMICALS""; ""ANTICHOLINERGIC CHEMICALS""; ""MORTALITY""; ""MORBIDITY""; ""Contents""; ""1 INTRODUCTION""; ""HISTORY OF THE EDGEWOOD TESTING PROGRAM""; ""PROCEDURES USED AT THE EDGEWOOD CHEMICAL TESTING PROGARM""; ""RECRUITMENT OF VOLUNTEERS""; ""GUIDELINES FOLLOWED IN THE PROTECTION OF SUBJECTS""; ""INVESTIGATORS""; ""SELECTION OF DOSES FOR HUMAN TESTS""; ""RANGE OF DOSES""; ""SAFETY MARGIN""; ""2 ANTICHOLINESTERASES""
""CHEMISTRY OF ANTICHOLINESTERASES""""“REVERSIBLE� INHIBITORS""; ""ORGANOPHOSPHORUS (OP) INHIBITORS""; ""ABSORPTION, FATE, AND EXCRETION OF ANTI-CHES""; ""MECHANISMS OF ACTION""; ""INHIBITION OF ACETYLCHOLINESTERASE BY ANTICHOLINESTERASES""; ""REACTIVATION OF ACHE""; ""AGING OF INHIBITED ACHE""; ""CHOLINERGIC RECEPTOR AND ACH CHANNEL""; ""PRESYNAPTIC ACTION""; ""NERVE MEMBRANE""; ""CENTRAL NERVOUS SYSTEM""; ""“NEUROTOXIC� ESTERASE (NTE)""; ""BIOCHEMICAL AND METABOLIC CHANGES""; ""OP ALKYLATION""; ""BIOLOGIC AND CLINICAL EFFECTS""; ""ACUTE EFFECTS: PHARMACOLOGY""; ""Eye""
""Gastrointestinal Tract""""Actions at Other Autonomic Sites""; ""Neuromuscular Junction""; ""Brain""; ""ACUTE TOXIC EFFECTS""; ""DELAYED NEUROPATHY (CNS-PNS DISTAL AXONOPATHY)""; ""Clinical Features""; ""Neuropathologic Features""; ""Neuropathic Potency""; ""LONG-TERM BRAIN DYSFUNCTION""; ""JUNCTIONAL NEUROMYOPATHY""; ""OTHER ADVERSE HEALTH EFFECTS""; ""Mutagenicity""; ""Carcinogenicity""; ""Fetal and Teratogenic Effects""; ""Effects on Male Reproduction""; ""Cataractogenic Effects""; ""Hemocoagulation""
""IMMEDIATE AND DELAYED EFFECTS IN VOLUNTEERS AFTER SINGLE OR REPEATED EXPOSURE TO ANTI-CHES AT EDGEWOOD""""MORTALITY DATA""; ""EVALUATION OF THE LIKELIHOOD OF LONG-TERM ADVERSE HEALTH EFFECTS""; ""BRAIN DYSFUNCTION""; ""JUNCTIONAL NEUROMYOPATHY AND DELAYED NEUROPATHY""; ""OTHER ADVERSE HEALTH EFFECTS""; ""Mutagenicity, Carcinogenicity, and Male Reproductive Effects""; ""Cataractogenicity""; ""Blood Changes""; ""CONCLUSIONS""; ""REFERENCES""; ""3 ANTICHOLINERGICS""; ""ATROPINE, SCOPOLAMINE, AND RELATED THERAPEUTIC ANTICHOLINERGIC CHEMICALS""; ""SITES OF ACTION""; ""PERIPHERAL EFFECTS""
""CENTRAL EFFECTS""""POISONING BY BELLADONNA ALKALOIDS""; ""SYMPTOMS AND SIGNS OF ATROPINE POISONING""; ""TREATMENT""; ""MECHANISM OF ACTION""; ""ABSORPTION, FATE, AND EXCRETION""; ""PHARMACOLOGICAL PROPERTIES OF SYNTHETIC ATROPINE DERIVATIVES""; ""ROLE OF DRUG DISPOSITION IN EXPLAINING DIFFERENCES AMONG ANTICHOLINERGIC COMPOUNDS""; ""ATROPINE""; ""BZ""; ""ANIMAL TOXICOLOGY OF ANTICHOLINERGIC COMPOUNDS""; ""IMMEDIATE EFFECTS""; ""EA 3443""; ""EA 3834""; ""LONG-TERM AND DELAYED EFFECTS""; ""Atropine""; ""Clidinium (Quartzan)""; ""Other Data""; ""HUMAN TOXICOLOGY OF ANTICHOLINERGIC COMPOUNDS""
Notes ""Dosing considerations""
Print version record
Subject Chemical warfare.
Cholinesterase inhibitors.
Parasympatholytic agents.
Chemical Warfare
Cholinesterase Inhibitors
Parasympatholytics
Chemical warfare
Cholinesterase inhibitors
Parasympatholytic agents
Form Electronic book
Author Chemicals, Panel on Anticholinergic
Toxicology, Committee on
ISBN 9780309593786
0309593786