Title Drug-induced liver toxicity / edited by Minjun Chen, Yvonne Will

Published New York, NY : Humana Press : Springer, [2018]

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Description 1 online resource (xx, 667 pages) : illustrations (some color) Series Methods in pharmacology and toxicology, 1557-2153 Methods in pharmacology and toxicology, 1557-2153 Contents Overview of mechanisms of drug-induced liver injury (DILI) and key challenges in DILI research / Nabil Noureddin and Neil Kaplowitz -- Detection, elimination, mitigation, and prediction of drug-induced liver injury in drug discovery / Francois Pognan -- Drug-induced liver injury (DILI) classification and its application on human DILI risk prediction / Shraddha Thakkar, Minjun Chen, Huixiao Hong, Zhichao Liu, Hong Fang, and Weida Tong -- Physicochemical properties and structural alerts / Lilia Fisk, Nigel Greene, and Russ Naven -- Quantitative structure-activity relationship models for predicting risk of drug-induced liver injury in humans / Huixiao Hong, Jieqiang Zhu, Minjun Chen, Ping Gong, Chaoyang Zhang, and Weida Tong -- Introduction to DILIsym® software, a mechanistic mathematical representation of drug-induced liver injury / Christina Battista, Brett A. Howell, Scott Q. Siler, and Paul B. Watkins -- Prediction of human liver toxicity using in vitro assays : limitations and opportunities / Franck A. Atienzar and Jean-Marie Nicolas -- Use of liver-derived cell lines for the study of drug-induced liver injury / Zhen Ren, Si Chen, Baitang Ning, and Lei Guo -- Evaluation of drug-induced liver injuries (DILI) with human hepatocytes : scientific rationale and experimental approaches / Albert P. Li -- Status and use of induced pluripotent stem cells (iPSCs) in toxicity testing / Min Wei Wong, Chris S. Pridgeon, Constanze Schlott, B. Kevin Park, and Christopher E.P. Goldring -- Engineered human liver cocultures for investigating drug-induced liver injury / Chase P. Monckton and Salman R. Khetani -- Status and future of 3D cell culture in toxicity testing / Monicah A. Otieno, Jinping Gan, and William Proctor -- Reactive metabolite assessment in drug discovery and development in support of safe drug design / Axel Pähler -- In vitro assessment of mitochondrial toxicity to predict drug-induced liver injury / Mathieu Porceddu, Nelly Buron, Pierre Rustin, Bernard Fromenty, and Annie Borgne-Sanchez -- Bile salt export pump : drug-induced liver injury and assessment approaches / Ruitang Deng -- High content screening for prediction of human drug-induced liver injury / Mikael Persson -- Interpretation, integration, and implementation of in vitro assay data : the predictive toxicity challenge / Deborah S. Light, Michael D. Aleo, and J. Gerry Kenna -- Perspectives on the regulatory and clinical science of drug-induced liver injury (DILI) / Mark I. Avigan and Monica A. Muñoz -- Regulatory toxicological studies : identifying drug-induced liver injury using nonclinical studies / Imran Khan and Elizabeth Hausner -- Hy's law and eDISH for clinical studies / John Senior and Ted Guo -- Variability in baseline liver test values in clinical trials : challenges in enhancing drug-induced liver injury assessment in subjects with liver disease / Bereket Tesfaldet, Gyorgy Csako, Tejas Patel, Md Shamsuzzaman, and Eileen Navarro Almario -- Postmarketing surveillance of drug-induced liver injury / S. Christopher Jones, Cindy Kortepeter, and Allen D. Brinker -- Host risk modifiers in idiosyncratic drug-induced liver injury (DILI) and its interplay with drug properties / Camilla Stephens, M. Isabel Lucena, and Raúl J. Andrade -- Human leukocyte antigen (HLA) and other genetic risk factors in drug-induced liver injury (DILI) / Ann K. Daly Immune mechanisms in drug-induced liver injury / Hartmut Jaeschke and Dean J. Naisbitt -- Translational and mechanistic biomarkers of drug-induced liver injury -- candidates and qualification strategies / Daniel J. Antoine -- Causality assessment methods in drug-induced liver injury / Rolf Teschke and Gaby Danan -- Circulating microRNAs as novel biomarkers of drug-induced liver injury in humans / Julian Krauskopf, Jos C. Kleinjans, and Theo M. de Kok -- Systems microscopy approaches in unraveling and predicting drug-induced liver injury (DILI) / Marije Niemeijer, Steven Hiemstra, Steven Wink, Wouter den Hollander, Bas ter Braak, and Bob van de Water -- Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury / J. Gerry Kenna, John C. Waterton, Andreas Baudy, Aleksandra Galetin, Catherine D.G. Hines, Paul Hockings, Manishkumar Patel, Daniel Scotcher, Steven Sourbron, Sabina Ziemian, and Gunnar Schuetz Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (SpringerProtocol, viewed March 21, 2018) Subject Hepatotoxicology -- Laboratory manuals Toxic hepatitis. Chemical and Drug Induced Liver Injury Drug Evaluation Toxicity Tests Pharmacology. Medical -- Pharmacology. Toxic hepatitis Hepatotoxicology Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Chen, Minjun, editor Will, Yvonne, editor ISBN 9781493976775 149397677X

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