Title Antiplatelet agents / Paolo Gresele [and others], editors

Published Berlin ; New York : Springer, ©2012

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Description 1 online resource : illustrations Series Handbook of experimental pharmacology, 0171-2004 ; v. 210 Handbook of experimental pharmacology ; v. 210. Contents 880-01 Part 1. Pathophysiology. Platelets: Production, Morphology and Ultrastructure / Jonathan N. Thon and Joseph E. Italiano -- Platelet Receptors / Alexandre Kauskot and Marc F. Hoylaerts -- Platelet Signaling / Timothy J. Stalker, Debra K. Newman, Peisong Ma, Kenneth M. Wannemacher and Lawrence F. Brass -- Platelet Interaction with the Vessel Wall / Philip G. de Groot, Rolf T. Urbanus and Mark Roest -- Platelets in Atherosclerosis and Thrombosis / Christian Schulz and Steffen Massberg 880-01/(S 3.2 Integrins3.2.1 α5β1; General Description; 3.2.2 α6β1; General Description; 3.2.3 αIIbβ3; Biochemical Description; Pathophysiology; 3.2.4 αvβ3; General Description; 3.3 Receptors in Amplification Phase; 3.3.1 P2Y1; Biochemical Description; Functional Variability; 3.3.2 P2Y12; Biochemical Description; Patient Bleeding; 3.3.3 P2X1; Description; 3.3.4 Thromboxane Receptor; Biochemical Description; Clinical Importance; 3.3.5 Prostaglandin E2 Receptors; Description; 3.3.6 Prostacyclin (PGI2) Receptor; Modification of IP and TP Function by Heterodimerization; Clinical Importance Part 2. Pharmacology. Aspirin and Other COX-1 Inhibitors / Carlo Patrono and Bianca Rocca -- Thienopyridines and Other ADP-Receptor Antagonists / Isabell Bernlochner and Dirk Sibbing -- Glycoprotein IIb/IIIa Antagonists / Karen M. Hook and Joel S. Bennett -- Targeting Phosphodiesterases in Anti-platelet Therapy / Matthew T. Rondina and Andrew S. Weyrich -- PAR-1 Inhibitors: A Novel Class of Antiplatelet Agents for the Treatment of Patients with Atherothrombosis / Sergio Leonardi and Richard C. Becker -- Thromboxane Receptors Antagonists and/or Synthase Inhibitors / Giovanni Davì, Francesca Santilli and Natale Vazzana -- Inhibitors of the Interaction Between von Willebrand Factor and Platelet GPIb/IX/V / Paolo Gresele and Stefania Momi -- Inhibitors of the Interactions Between Collagen and Its Receptors on Platelets / Hans Deckmyn, Simon F. De Meyer, Katleen Broos and Karen Vanhoorelbeke -- Intracellular Signaling as a Potential Target for Antiplatelet Therapy / Patrick Andre -- Novel Targets for Platelet Inhibition / Kathleen Freson and Chris Van Geet -- Variability of Platelet Indices and Function: Acquired and Genetic Factors / Giovanni de Gaetano, Iolanda Santimone, Francesco Gianfagna, Licia Iacoviello and Chiara Cerletti -- Small RNAs as Potential Platelet Therapeutics / Leonard C. Edelstein and Paul F. Bray -- Pharmacological Modulation of the Inflammatory Actions of Platelets / Richard Amison, Clive Page and Simon Pitchford Part 3. Therapy. The Role of Laboratory Monitoring in Antiplatelet Therapy / Marco Cattaneo -- Antiplatelet Agents in Ischemic Heart Disease / Christopher H. May and A. Michael Lincoff -- Antiplatelet Therapy in Cerebrovascular Disorders / Ralph Weber, Johannes Brenck and Hans-Christoph Diener -- Antiplatelet Therapy in Peripheral Artery Disease / Francesco Violi, Stefania Basili, Jeffrey S. Berger and William R. Hiatt -- Primary Prevention of Ischaemic Cardiovascular Disorders with Antiplatelet Agents / Tom Meade Summary Antiplatelet therapy is the cornerstone of treatment of ischemic cardiovascular disease and over the last few years spectacular advancements in this field have been recorded. This is the first comprehensive handbook entirely dedicated to all the aspects of antiplatelet therapy. The book is divided into three main sections, pathophysiology, pharmacology and therapy, for a total of 23 chapters. A large group of leading experts from different European countries and from the USA, both from academia and industry, have contributed to the book. Besides a detailed overview on the pharmacology and clinical applications of all the currently used or of the novel antiplatelet agents, innovative approaches (e.g. intracellular signalling as an antiplatelet target, small RNAs as platelet therapeutics, etc.) or unconventional aspects (e.g. pharmacologic modulation of the inflammatory action of platelets are also treated. The book is oriented to both basic investigators and to clinicians involved with research on platelet inhibition or with the clinical use of antiplatelet therapies Analysis Medicine Toxicology Internal medicine Biomedicine Pharmacology/Toxicology Molecular Medicine geneeskunde farmacologie pharmacology toxicologie biomedische wetenschappen neurologie neurology cardiologie cardiology Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes English Subject Hematologic agents. Blood platelets. Blood platelet disorders. Blood-vessels -- Diseases. Therapeutics. Life sciences. Diseases. Blood -- Diseases. Brain -- Diseases. Physical sciences. Central nervous system -- Diseases. Nervous system -- Diseases. Chemotherapy. Cardiovascular system -- Diseases. Pharmacology. Platelet Aggregation Inhibitors -- therapeutic use Cardiovascular Diseases -- drug therapy Cerebrovascular Disorders -- drug therapy Platelet Aggregation Inhibitors -- pharmacology Vascular Diseases Therapeutics Biological Science Disciplines Hematologic Agents Disease Hematologic Diseases Brain Diseases Natural Science Disciplines Hemic and Lymphatic Diseases Analytical, Diagnostic and Therapeutic Techniques and Equipment Central Nervous System Diseases Therapeutic Uses Disciplines and Occupations Nervous System Diseases Pharmacologic Actions Chemical Actions and Uses Chemicals and Drugs Platelet Aggregation Inhibitors Cerebrovascular Disorders Drug Therapy Stroke Blood Platelet Disorders Cardiovascular Diseases Pharmacology Blood Platelets biological sciences. physical sciences. pharmacology. treating (health care function) MEDICAL -- Pharmacology. Therapeutics Physical sciences Pharmacology Nervous system -- Diseases Life sciences Diseases Chemotherapy Central nervous system -- Diseases Cardiovascular system -- Diseases Brain -- Diseases Blood-vessels -- Diseases Blood -- Diseases Blood platelet disorders Blood platelets Hematologic agents Form Electronic book Author Gresele, Paolo, 1953- ISBN 9783642294235 3642294235 9783642294228 3642294227

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