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Title Non-neuronal mechanisms of brain damage and repair after stroke / Jun Chen, John H. Zhang, Xiaoming Hu, editors
Published Switzerland : Springer, 2016

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Description 1 online resource (xiii, 408 pages) : illustrations, photographs, many in color
Series Springer series in translational stroke research
Springer series in translational stroke research.
Contents Part I. Microvascular integrity in stroke ; Structural alterations to the endothelial tight junction complex during stroke / Anuska V. Andjelkovic and Richard F. Keep -- Role of pericytes in neurovascular unit and stroke / Turgay Dalkara, Luis Alarcon-Martinez, and Muge Yemisci -- Glial support of blood-brain barrier integrity : molecular targets for novel therapeutic strategies in stroke / Patrick T. Ronaldson and Thomas P. Davis -- Barrier mechanisms in neonatal stroke / Zinaida S. Vexler -- Angiogenesis : a realistic therapy for ischemic stroke / Ke-Jie Yin and Xinxin Yang
Part II. Glial cells in stroke ; Astrocytes as a target for ischemic stroke / Shinghua Ding -- Microglia : a double-sided sword in stroke / Hong Shi, Mingyue Xu, Yejie Shi, Yanqin Gao, Jun Chen, and Xiaoming Hu -- Crosstalk between cerebral endothelium and oligodendrocyte after stroke / Akihiro Shindo, Takakuni Maki, Kanako Itoh, Nobukazu Miyamoto, Naohiro Egawa, Anna C. Liang, Takayuki Noro, Josephine Lok, Eng H. Lo, and Ken Arai
Part III. Peripheral immune cells in stroke ; The peripheral immune response to stroke / Josef Anrather -- The role of spleen-derived immune cells in ischemic brain injury / Heng Zhao -- Regulatory T cells in ischemic brain injury / Arthur Liesz -- B-cells in stroke and preconditioning-induced protection against stroke / Uma Maheswari Selvaraj, Katie Poinsatte, and Ann M. Stowe -- Mast cell as an early responder in ischemic brain injury / Perttu J. Lindsberg, Olli S. Mattila, and Daniel Strbian -- Roles of neutrophils in stroke / Glen C. Jickling and Frank R. Sharp -- The function of cytokines in ischemic stroke / Christopher C. Leonardo and Keith R. Pennypacker
Part IV. White matter injury and repair in stroke ; Ischemic injury to white matter : an age-dependent process / Sylvain Brunet, Chinthasagar Bastian, and Selva Baltan
Part V. Emerging therapies to target non-neuronal mechanisms after stroke ; Neurovascular repair after stroke / Sherrefa R. Burchell, Wing-Mann Ho, Jiping Tang, and John H. Zhang -- The role of nonneuronal Nrf2 pathway in ischemic stroke : damage control and potential tissue repair / Tuo Yang, Yang Sun, and Feng Zhang -- Stem cell therapy for ischemic stroke / Hung Nguyen, Naoki Tajiri, and Cesar V. Borlongan
Summary This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials
Bibliography Includes bibliographical references at chapter ends
Notes Online resource; title from PDF title page (SpringerLink, viewed August 23, 2016)
Subject Cerebrovascular disease -- Molecular aspects
Brain damage -- Molecular aspects
Cerebral ischemia.
Brain Ischemia
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Cerebral ischemia
Genre/Form Electronic books
Form Electronic book
Author Chen, Jun (Professor of neurology and pharmacology), editor, author.
Hu, Xiaoming, active 2014, editor, author.
Zhang, J. H. (John H.), editor, author.
ISBN 9783319323374
3319323377