Limit search to available items
Book Cover

Title Beyond apoptosis : cellular outcomes of cancer therapy / edited by Igor B. Roninson, J. Martin Brown, Dale E. Bredesen
Published New York : Informa Healthcare, ©2008


Description 1 online resource (xi, 352 pages) : illustrations
Contents A personal history of the development of the apoptosis concept / John F.R. Kerr -- What do the clinical data tell us about the role of apoptosis in sensitivity to cancer therapy? / George D. Wilson -- Response of solid tumors to cancer therapy : how relevant is apoptosis? / J. Martin Brown -- Historical studies of various forms of programmed cell death / Richard A. Lockshin and Zahra Zakeri -- Toward a mechanistic taxonomy for programmed cell death pathways / Dale E. Bredesen -- Caspase-independent apoptotic cell death / Lotti Egger -- Autophagic cell death in mammalian cells / David T. Madden -- The cellular decision between apoptosis and autophagy / Yongjun Fan, Erica Ullman, and Wei-Xing Zong -- Parthanatos : PARP and AIF-dependant programmed cell death / Valina L. Dawson and Ted M. Dawson -- Paraptosis / Sabina Sperandio and Ian de Belle -- Cellular senescence and its effects on carcinogenesis / Judith Campisi -- Tumor-suppressing activities of senescent keratinocytes / Brian J. Nickoloff -- Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells / Daniel DiMaio [and others] -- Treatment-induced tumor cell senescence and its consequences / Igor B. Roninson and Eugenia V. Broude -- Senescence regulation in cancer therapy / Abdelhadi Rebbaa -- Exploiting drug-induced senescence in trasgenic mouse models / Mehtap Kilic and Clemens A. Schmitt -- Therapy-induced cellular senescnece : clinical relevance, implications, and applications / Daniel Y. Wu [and others] -- Mitotic catastrophe in cancer therapy / Eugenia V. Broude [and others] -- How do cells die after irradiation? Time-lapse studies of cells in culture / William C. Dewey -- Modes of cell death by anticancer agents : the crucial importance of dose / J. Martin Brown
Summary Apoptosis, the process of deliberate cell death within a multi-cellular organism, has been linked to both the development and the demise of cancer causing cells. Vast research has been conducted on combating cancer cells through apoptosis in radiation and chemotherapy, however, apoptosis plays only a limited role in determining the success of cancer therapy. This realization has been the catalyst necessary to examine alternative mechanisms for the anti-proliferative action of anticancer agents, as well as moving forward in the complete eradication of cancer. The goal of Beyond Apoptosis: Cellu
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cancer -- Chemotherapy.
Antimitotic agents.
Antineoplastic agents.
Neoplasms -- drug therapy
Medical Oncology
Antimitotic Agents
Antineoplastic Agents
Apoptosis -- drug effects
Cellular Senescence -- drug effects
Mitosis -- drug effects
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Antineoplastic agents
Antimitotic agents
Cancer -- Chemotherapy
Form Electronic book
Author Roninson, Igor B.
Brown, J. M. (J. Martin)
Bredesen, Dale E.
ISBN 9781420020502