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Author Herbert, Alan (Alan Gordon), author.

Title Flipons : the discovery of Z-DNA and soft-wired genomes / Alan Herbert
Edition First edition
Published Boca Raton, FL : CRC Press, 2024


Description 1 online resource
Contents The Dawn -- Even smart people are sometimes wrong -- Coming to America -- From One Unknown to Another -- Failing successfully everywhere else. The in-between years -- How do you know it's you? The answer lies in your Z-RNA -- Can left-handed Z-DNA and Z-RNA kill you? -- Does Z-DNA regulate transcription? -- Luck and the Business of Science -- What about other types of flipons? -- Is your genome soft-wired? -- How do you assemble a soft-wired genome? -- How do you program a soft-wired genome? -- Is life intransitive? -- Are RNA therapeutics the wave of the future? -- Epilogue: Why have a career in science?
Summary "Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles in the programmed cell death of aging cells. Other types of flipon exist and alter the readout of transcripts from the genome, encoding genetic information by their shape rather than by their sequence. Many of these flipons are within repeat elements that were previously considered to be just genomic junk. Instead these genetic elements increase the adaptability of cells by flipping DNA conformation. By acting as digital switches, the different flipon types can alter cellular responses without any change to their sequence or any damage to DNA. These highly dynamic structures enable the rapid evolution of multicellular organisms. The junk DNA in repeats also encode peptide patches that enables the assembly of cellular machines, The intransitive logic involved enhances the chance of an individuals surviving a constantly changing environment"-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Description based on print version record and CIP data provided by publisher; resource not viewed
Subject DNA, Z-Form -- genetics
RNA -- genetics
Genome -- genetics
Nucleic Acid Conformation
Cell Death -- genetics
Genetics -- history
History, 20th Century
History, 21st Century
SCIENCE / Life Sciences / Biochemistry
MEDICAL / Biochemistry
MEDICAL / Microbiology
Genre/Form Personal narratives.
R├ęcits personnels.
Form Electronic book
LC no. 2023053539
ISBN 9781003463535