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Title Two faces of evil : cancer and neurodegeneration / Thomas Curran, Yves Christen, editors
Published Berlin ; Heidelberg ; New York : Springer, ©2011


Description 1 online resource (xiii, 163 pages) : illustrations
Series Research and perspectives in alzheimer's disease
Research and perspectives in Alzheimer's disease.
Contents Two Faces of Evil: Cancer and Neurodegeneration; Foreword; Acknowledgments; Contents; Contributors; Updating the Mammalian Cell Cycle: The Role of Interphase Cdks in Tissue Homeostasis and Cancer; 1 Mammalian Cdks and the Classical Cell Cycle Model; 2 Interphase Cdks are Not Essential for the Mammalian Cell Cycle; 3 Limited Compensatory Activities Among Interphase Cdks; 4 Interphase Cdks Have Evolved to Drive Proliferation of Highly Specialized Cells; 5 Cell Cycle Cdks and Cancer; 6 Are Interphase Cdks Required for Tumor Development?; References
The Role of Cdk5 as a Cell Cycle Suppressor in Post-mitotic Neurons1 Introduction; 2 Cdk5 Plays an Important Role in Neuronal Development; 3 Cdk5 Serves Important Functions in the Regulation of Synaptic Function; 4 Cdk5 is a Cell Cycle Suppressor in Post-mitotic Neurons; 5 Cdk5 Inhibits the Cell Cycle in a Kinase-Independent Fashion; 6 Cdk5 Inhibits the Cell Cycle by Sequestering E2F1; 7 The Implications of the Central Role of Cdk5 in Neuronal Cell Cycle Suppression; References; Actin-SRF Signaling in the Developing and Mature Murine Brain; 1 Principles of Actin-SRF Signaling in Brain Cells
1.1 Actin Dynamics Regulates Gene Expression Upon Activation of MRTF-SRF Signaling1.2 Actin Dynamics in Neuronal Network Assembly; 1.3 Actin-MRTF-SRF interplay in Neuronal Signaling; 2 Essential functions of SRF and MRTF in Mouse Brain Development; 2.1 Embryonic Neuronal Migration; 2.2 Axonal Outgrowth, Guidance, and Synaptic Targeting; 3 Functional Actin-SRF Interplay in the Mature Brain; 3.1 Activity-Induced Gene Expression; 3.2 Learning and Memory; 4 Linking SRF to Neurodegenerative Diseases, Psychiatric Disorders, and Addiction
4.1 SRF Protects Against Axonal De-myelination and Degeneration4.2 SRF and Epileptic Seizure-Induced Neuronal IEG Expression; 4.3 SRF in M. Alzheimer; 4.4 SRF as a Novel Player in Addictive Behavior and Hyperactive Disorder; References; The E3 Ubiquitin Ligase Ube3A Regulates Synaptic Function Through the Ubiquitination of Arc; 1 A Role for Ube3A in Human Disorders of Cognitive Function; 2 Ube3a is a Neuronal Activity-Regulated Gene; 3 Regulation of Synaptic AMPA Receptor Function by Ube3A; 4 A Novel Proteomic Approach to Ube3A Substrate Identification
5 Arc is a Neuronal Ube3A Substrate that Mediates the Effect of Ube3A on AMPAR Trafficking6 Discussion; References; Targeting Children ́s Brain Tumors: Development of Hedgehog Pathway Inhibitors for Medulloblastoma; 1 Introduction; 2 Role of the Hh Pathway in Medulloblastoma; 3 Targeting Smoothened; 4 Hh Pathway is Downregulated in Tumor Cell Lines; 5 Direct Allografts Retain Hh Pathway Activity; 6 Testing Targeted Therapies in Mice; 7 HhAntag Eradicates Large Tumors in PtchI+/-p53-/- Mice; 8 Hh Pathway Inhibition Causes Bone Defects in Young Mice; 9 Inhibiting the Hh Pathway in the Clinic
Summary Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profo
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Cytology -- Congresses
Cells -- Growth -- Congresses
Cell death -- Congresses
Tumors -- Growth -- Congresses
Nervous system -- Degeneration -- Congresses
Homeostasis -- physiology
Cell Proliferation
Cell Death
Neoplasms -- etiology
Alzheimer Disease -- etiology
Nerve Degeneration -- physiopathology
SCIENCE -- Life Sciences -- Cell Biology.
Cell death
Cells -- Growth
Nervous system -- Degeneration
Tumors -- Growth
Genre/Form proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Curran, Thomas
Christen, Yves.
ISBN 9783642166020