Title Design of caspase inhibitors as potential clinical agents / editor(s), Tom O'Brien, Steven D. Linton

Published Boca Raton : Taylor & Francis, 2009

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Description 1 online resource ([xii] 299 pages) : illustrations Series CRC enzyme inhibitors series CRC enzyme inhibitors series. Contents Mammalian caspase activation pathways in apoptosis and inflammation / Susan Logue and Seamus Martin -- Role of caspases in inflammatory diseases / Kristof Kersse [and others] -- Role of caspases in apoptotic-driven indications / Takashi Matsui -- Kinetics and catalytic activity of caspases / Kip Nalley -- Non-peptide small molecule inhibitors of caspases / Alexandre Ivachtchenko [and others] -- Identification of inflammatory caspase inhibitors / John Wos and Thomas Demuth Jr -- Identification of apoptotic caspase inhibitors / Brett Ullman -- Discovery of a first-in-class apoptotic caspase inhibitor, emricasan (pf-03491390/idn-6556) / Niel Holgen -- Novel approaches to caspase inhibitor discovery / Justin Scheer and Michael Romanowski -- Therapeutic potential for caspase inhibitors : present and future / Hiroyuki Eda Bibliography Includes bibliographical references and index Notes Print version record Subject Cysteine proteinases. Cysteine proteinases -- Inhibitors. Apoptosis. Caspase Inhibitors Cysteine Endopeptidases Cysteine Proteinase Inhibitors Apoptosis Caspases -- physiology Caspases -- therapeutic use SCIENCE -- Life Sciences -- Biochemistry. Apoptosis Cysteine proteinases Cysteine proteinases -- Inhibitors Form Electronic book Author O'Brien, Tom Linton, Steven D. ISBN 9781420045413 1420045415

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