Description |
1 online resource (x, 454 pages) : illustrations (some color) |
Series |
Handbook of experimental pharmacology ; v. 201 |
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Handbook of experimental pharmacology ; v. 201.
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Contents |
Drug Transporters; Preface; Contents; Contributors; Uptake Transporters of the Human OATP Family; In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) in Drug Therapy; Organic Cation Transporters (OCTs, MATEs), In Vitro and In Vivo Evidence for the Importance in Drug Therapy; Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition; The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation |
Summary |
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies |
Analysis |
farmacologie |
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pharmacology |
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toxicologie |
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toxicology |
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biomedische wetenschappen |
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biomedicine |
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lever |
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liver |
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geneeskunde |
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medicine |
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geneesmiddelresistentie |
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drug resistance |
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fysiologie |
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physiology |
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spijsverteringsstelsel |
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digestive system |
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Medicine (General) |
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Geneeskunde (algemeen) |
Bibliography |
Includes bibliographical references and index |
Subject |
Carrier proteins.
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Pharmacology.
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Pharmacokinetics.
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Membrane Transport Proteins -- physiology
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Biological Transport -- physiology
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Carrier Proteins
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Pharmacology
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Pharmacokinetics
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pharmacology.
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SCIENCE -- Life Sciences -- Biochemistry.
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Pharmacokinetics
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Carrier proteins
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Pharmacology
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Form |
Electronic book
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Author |
Fromm, Martin F
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Kim, Richard B.
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ISBN |
9783642145414 |
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3642145418 |
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364214540X |
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9783642145407 |
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