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Book Cover
E-book

Title Drug transporters / Martin F. Fromm, Richard B. Kim, editors
Published Heidelberg ; New York : Springer-Verlag Berlin Heidelberg, ©2011

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Description 1 online resource (x, 454 pages) : illustrations (some color)
Series Handbook of experimental pharmacology ; v. 201
Handbook of experimental pharmacology ; v. 201.
Contents Drug Transporters; Preface; Contents; Contributors; Uptake Transporters of the Human OATP Family; In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) in Drug Therapy; Organic Cation Transporters (OCTs, MATEs), In Vitro and In Vivo Evidence for the Importance in Drug Therapy; Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition; The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation
Summary It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies
Analysis farmacologie
pharmacology
toxicologie
toxicology
biomedische wetenschappen
biomedicine
lever
liver
geneeskunde
medicine
geneesmiddelresistentie
drug resistance
fysiologie
physiology
spijsverteringsstelsel
digestive system
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Subject Carrier proteins.
Pharmacology.
Pharmacokinetics.
Membrane Transport Proteins -- physiology
Biological Transport -- physiology
Carrier Proteins
Pharmacology
Pharmacokinetics
pharmacology.
SCIENCE -- Life Sciences -- Biochemistry.
Pharmacokinetics
Carrier proteins
Pharmacology
Form Electronic book
Author Fromm, Martin F
Kim, Richard B.
ISBN 9783642145414
3642145418
364214540X
9783642145407