| Description |
1 online resource (517 p.) |
| Contents |
Intro -- Foreword -- Contents -- About the Editor -- 1: Recent Advances in In Vitro Generation of Mature Cardiomyocytes -- 1.1 Introduction -- 1.2 Mature Cardiomyocyte Internal Complexity -- 1.3 CM Differentiation Protocols -- 1.3.1 Hormones -- 1.3.2 Energy Source -- 1.3.3 Prolonged Culture Period -- 1.3.4 Cellular Interactions -- 1.3.5 Biophysical Stimulation -- 1.3.6 Substrate Stiffness -- 1.3.7 Micropatterning -- 1.4 3D Culture System -- 1.5 Bioprinting -- 1.6 Microelectrode Cultured CM -- 1.7 Conclusion and Future Challenges -- References |
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2: Cardiac Reprogramming with Stem Cells: An Advanced Therapeutic Strategy in Advanced Heart Failure -- 2.1 Introduction -- 2.2 Advanced Heart Failure: Definition and Contemporary Strategy -- 2.3 Modality of Action and Targets for Cell Care in Advanced HF -- 2.4 Cell Therapy in Advanced HF -- 2.4.1 Induced Pluripotent Stem Cells -- 2.4.2 Endothelial Progenitor Cells and Bone Marrow Mononuclear Cells -- 2.4.3 Cardiac Stem Cells -- 2.4.4 Mesenchymal Stem Cells -- 2.4.5 Skeletal Myoblasts -- 2.5 Future Directions for Investigations -- 2.6 Conclusion -- References |
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3: Induced Pluripotent Stem Cells and Allogeneic Mesenchymal Stem Cell Therapy in Cardiovascular Diseases -- 3.1 Introduction -- 3.2 Allogeneic Cell Therapy -- 3.2.1 Moving Towards Allogeneic Cell Therapy -- 3.2.2 Cellular Recognition -- 3.2.3 Production Technology -- 3.2.4 Preclinical and Clinical Allogeneic Experience -- 3.2.4.1 Safety -- 3.2.4.2 Efficacy -- 3.2.4.3 Perspectives -- 3.3 Induced Pluripotent Stem Cells -- 3.3.1 iPSCs and Cardiomyocytes Maturation -- 3.3.2 iPSCs Maturation -- 3.3.3 Long QT Syndrome -- 3.3.4 Hypertrophic Cardiomyopathy and Dilated Cardiomyopathy |
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3.3.5 Brugada Syndrome -- 3.3.6 Familial Arrhythmogenic Right Ventricular Dysplasia -- 3.3.7 Biological Pacemakers -- 3.3.8 Status of iPSCs in the Treatment of Heart Failure -- 3.4 Administration Routes for Advanced Therapy Medicinal Products in Patients with Cardiovascular Diseases -- 3.4.1 Cell/ATMPs Currently Proposed Delivery Routes -- 3.4.1.1 Peripheral Intravenous Injections -- 3.4.1.2 Intracoronary Injections -- 3.4.1.3 Intramyocardial Injections -- 3.4.1.4 Transendocardial Approach -- 3.4.1.4.1 Electromechanically-Guided Procedure -- 3.4.1.4.2 Fluoroscopy-Guided Procedures |
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3.4.1.5 Transepicardial Approaches -- 3.4.1.5.1 Surgical Approach -- 3.4.1.5.2 Minimally Invasive Approach -- 3.4.1.5.3 Intrapericardial Approach -- 3.5 Conclusions -- References -- 4: ̀̀Heart Cells ́́Derived from Pluripotent Stem Cells and Therapeutic Applications -- 4.1 Introduction -- 4.2 Induced Pluripotent Stem Cell Sources -- 4.3 Cardiomyocytes -- 4.3.1 iPSC-Derived Cardiomyocyte Differentiation and Manufacturing Protocols -- 4.3.2 iPSC-Derived Cardiomyocyte Transplantation and Large Animal Studies -- 4.3.3 iPSC-Derived Cardiomyocyte Transplantation and Clinical Trials |
| Summary |
The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes, their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy |
| Notes |
4.4 Cardiac Progenitor Cells |
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Description based on online resource; title from digital title page (viewed on October 06, 2023) |
| Subject |
Stem cells -- Therapeutic use
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Cardiovascular system -- Diseases -- Treatment -- Technological innovations
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| Form |
Electronic book
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| Author |
Haider, Khawaja Husnain.
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| ISBN |
9819907225 |
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9789819907229 |
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