| Description |
1 online resource |
| Series |
Advances in biochemistry in health and disease ; volume 20 |
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Advances in biochemistry in health and disease ; v. 20.
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| Contents |
Intro -- Preface -- Contents -- Contributors -- Part IPathophysiology of Cardiovascular Complications in Obesity -- 1 Different Faces of Obesity in Cardiovascular Diseases: Culprit or Protector -- Introduction and Epidemiology -- Definition -- Obesity and Cardiovascular Disease -- Obesity and CVD Risk Factors -- Metabolic Syndrome -- Diabetes Mellitus -- Hypertension -- Dyslipidemia -- Obesity and Atrial Fibrillation -- Obesity and Heart Failure -- Obesity and Depression and Physical Activity -- Obesity Paradox -- Conclusions -- References |
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2 Obesity-Induced Cardiovascular Complications and Therapeutic Intervention -- Introduction -- Obesity Paradox -- Epidemiology of Obesity and Cardiovascular Complication -- Obesity-Induced Cardiovascular Complications: Role of Adipose Tissues -- Adverse Effects of Obesity on the Cardiovascular System -- Heart Failure -- Atherosclerosis -- Coronary Artery Disease -- Haemodynamic Changes -- Hypertension -- Pulmonary Arterial Hypertension -- Cardiac Hypertrophy -- Congenital Heart Disease -- Cardiac Arrhythmias and Sudden Cardiac Death -- Myocardial Infarction |
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NAFLD Is a Risk Factor for Cardiovascular Complications in Obesity -- Prevention and Treatment Options for the Management of Obesity and CVD -- Conclusions -- References -- 3 Maternal Obesity: Impacts on the Cardiovascular Health of Mother and Offspring -- Introduction -- Cardiovascular Risks Associated with Maternal Obesity -- Maternal Hypertension and Cardiac Dysfunction -- Congenital Heart Defects -- Mechanisms of Maternal Obesity and Related Cardiovascular Complications in Their Offspring -- Hormone-Mediated Responses -- Inflammation-Mediated Responses -- Oxidative Stress-Mediated Responses |
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Clinical Management of Maternal Obesity -- References -- 4 Role of Liver X Receptor in Cardiovascular Diseases -- Introduction -- Liver X Receptors -- Physiological Functions of LXRs -- LXR in Cardiovascular Diseases -- Atherosclerosis -- Myocardial Ischemia/Repurfusion Injury (MI/RI) -- Diabetic Cardiomyopathy (DCM) -- Cardiac Hypertrophy -- Cardiac Fibrosis -- Conclusions -- References -- 5 Role of NLRP3 Inflammasomes in Obesity-Induced Cardiovascular Diseases -- Introduction -- NLRP3 Inflammasome as a Sensor of Inflammation |
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Activation of Inflammasome in Obesity-Induced Cardiovascular Diseases -- The NLRP3 Inflammasome and Obesity -- The NLRP3 Inflammasome in Obesity Induced Cardiovascular Diseases -- NLRP3 Inflammasome in Atherosclerosis -- NLRP3 Inflammasome in Hypertension -- NLRP3 Inflammasome in Myocardial Infarction and Cardiac Remodeling -- Therapeutic Strategies Targeting Inflammasome -- Summary -- References -- 6 Vicious Link of Obesity with Cardiometabolic and Renal Diseases -- Introduction -- Obesity-Induced Cardiovascular Disorders -- Obesity-Induced T2D and Associated Complications |
| Summary |
Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters). The intent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system. In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities |
| Notes |
Includes index |
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Description based on online resource; title from digital title page (viewed on November 24, 2020) |
| Subject |
Cardiovascular system -- Diseases.
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Cardiovascular system -- Pathophysiology
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Obesity -- Complications
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Cardiovascular Diseases
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Obesity -- Complications
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Cardiovascular system -- Pathophysiology
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Cardiovascular system -- Diseases
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Human physiology
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| Form |
Electronic book
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| Author |
Tappia, Paramjit S., editor.
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Bhullar, Sukhwinder K., editor
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Dhalla, Naranjan S., editor.
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| ISBN |
9783030473365 |
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3030473368 |
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