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Book Cover
Author Thiriet, Marc

Title Tissue functioning and remodeling in the circulatory and ventilatory systems / by Marc Thiriet
Published New York ; London : Springer, 2013


Description 1 online resource
Series Biomathematical and biomechanical modeling of the circulatory and ventilatory systems ; v. 5
Biomathematical and biomechanical modeling of the circulatory and ventilatory systems ; v. 5.
Contents Blood -- Hematopoiesis -- Blood Cells -- Lymph Drainage -- Cardiomyocytes -- Heart Wall -- Vessel Wall -- Smooth Myocytes -- Vascular Endothelium -- Vasculature Growth -- Tissue Development, Repair, and Remodeling -- Airway Surface Liquid and Respiratory Mucus -- Surfactant -- Conclusion
Summary The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training. Reviews structure and function of major constituents of the circulatory and respiratory apparatusDescribes major cellular processes involved in signaling, interactions, and adaptive responses of physiological conduitsIntegrates biology, chemistry, and physics for the multidisciplinary exploration and modeling of physiological flowsFocuses on mechanotransduction-induced regulation
Notes Print version record
Subject Cardiovascular system -- Mechanical properties
Respiratory organs -- Mechanical properties
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Biomedical engineering.
Fluid mechanics.
Systems biology.
Genre/Form Electronic books
Form Electronic book
ISBN 9781461459668