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Author Spector, Peter, author.

Title Understanding atrial fibrillation / Peter Spector
Published Hoboken, NJ : Wiley Blackwell, 2020
Online access available from:
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Description 1 online resource (xiii, 168 pages)
Contents Intro; Title Page; Contents; Preface; Acknowledgments; Part I Building blocks of fibrillation; Excitation and propagation; Source-sink relationships; What determines source-sink balance?; Propagation and reentry; Requirements for reentry; What makes a circuit?; Source-sink balance and rotors; Wave length; Wave length, path length, and reentry; Restitution; Initiating reentry; A Deeper look at circuits; Part II Atrial fibrillation mechanisms; The evolution of current concepts; Focal or disseminated?; Multiwavelet reentry moves to the forefront; The mass hypothesis of atrial fibrillation
Is fibrillatory conduction active or passive?Can fibrillatory conduction be active?; Impact of a structural reentrant circuit on the average duration of multiwavelet reentry; Location of atrial fibrillation drivers; Regional gradients; Which driver type and where?; Why are fast sites fast?; Impact of regional heterogeneity on the dynamics of atrial fibrillation drivers; Tissue properties and spatial stability; Cores in the setting of interactions with other waves; Variable meander distance and rotor distribution; Where are driver sites?
James cox: leveraging the mass hypothesisPrinciples of propagation: Implications for fibrillation; Multi-wavelet reentry; Multi-wavelet reentry: the probabilistic formulation; Collision probability; Episode duration and collision probability; Quantifying the propensity to perpetuate multi-waveletre entry; Predicting the impact of ablation; Predicting the impact of ablation in heterogeneous tissue; Geometric optimization; Focal rotors; Micro- reentry; Endocardial/epicardial discontinuities and atrial fibrillation; Anchoring of moving circuits; Fibrillatory conduction or multi-wavelet reentry?
Principles of propagation: Driver interactions in fibrillationWaves and wave sources; Where waves collide; Two wave sources at the same rate; Two wave sources at different rates; Sources with variable rates; Source-source interaction: who influences whom?; Part III Working with incomplete information; Cardiac mapping; Sampling and interpolation; The image processing analogy for cardiac mapping; Sample density and sequential mapping; Currents sources and potential fields; Who cares about spatial resolution?; Fractionation results from inadequate spatial resolution; Dominant frequency mapping
Spatial resolution and electrogram frequencyWhat determines spatial resolution?; Electrode design and spatialre solution; Quantifying spatial resolution; Recording configuration and spatial resolution; Orthogonal close unipolar (direction independence and maximum spatial resolution); Sample density and atrial fibrillation; Multi-site simultaneous mapping; Sequential mapping of atrial fibrillation; Complex fractionated atrial electrogram mapping; Dominant frequency mapping; Mapping fibrosis; Mapping rotors; Mapping atrial fibrillation reconsidered
Summary "Physicians today are being presented with voluminous and conflicting information about the mechanisms responsible for AF, the tools to identify its drivers and the strategies appropriate for its treatment. This book is meant to provide physicians with the information and analytic tools required interpret the studies that purport to solve the AF puzzle. The aim of the book is to 1) explain the mechanisms responsible for initiating and perpetuating AF by building from fundamental electrophysiologic principles, 2) review the experimental data that has shaped our current understanding of AF, 3) describe the analytic methods used to interpret the experimental data, 4) explore the implications that the above information has with regard to mapping and ablation of AF. The book will be written from first principles, it is designed for readers with a foundation in electrophysiology. The intended audience is physicians, fellows, residents, electrophysiology lab staff and industry personnel interested in treating atrial fibrillation"--Provided by publisher
Bibliography Includes bibliographical references and index
Notes Online resource; title from digital title page (viewed on October 18, 2019)
Subject Atrial Fibrillation -- diagnosis.
Atrial Fibrillation -- physiopathology.
Cardiac Electrophysiology -- methods.
Electrophysiologic Techniques, Cardiac -- methods.
Models, Cardiovascular.
Atrial fibrillation.
Atrial fibrillation.
MEDICAL -- Cardiology.
Form Electronic book
LC no. 2019015570
ISBN 111952461X