Human cancer genetics -- Genetic toxicity for predicting carcinogenicity -- Genotoxic and nongenotoxic mechanisms of carcinogenesis -- Structure-activity relationship (SAR) and its role in cancer risk assessment -- Regulatory genetic toxicology tests -- Complementary genetic toxicology assays -- The mouse lymphoma assay (MLA) using the microwell method -- The in vivo micronucleus assay -- ICH guidances on genotoxicity and carcinogenicity: scientific background and regulatory practice -- New OECD genetic toxicology guidelines and interpretation of results -- Dose-response relationships in chemical carcinogenesis and cancer risk assessment -- Molecular epidemiology and biomarkers -- Quantitative cancer risk assessment of nongenotoxic carcinogens -- Risk assessment of genotoxic carcinogens -- Biologically based cancer risk assessment models
Summary
This work reviews the roles of genetic toxicology in cancer risk assessment conducted by regulatory agencies worldwide - discussing hazard identification, dose-response relationships, exposure assessment and practices of risk characterization
