| Description |
1 online resource |
| Series |
Microbiology research andvances |
|
Animal science, issues and professions |
|
Microbiology research advances series.
|
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Animal science, issues, and professions series.
|
| Contents |
ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; Contents ; Preface ; Murine Models of Sporadic and Inflammation-Related Colon Carcinogenesis with Particular Focus on the AOM/DSS Chemically Induced Colorectal Cancer Model ; Abstract ; Introduction ; A Variety of CRC Models: Benefits and Limits ; Chemically Induced Colon Carcinogenesis in Rodents ; The AOM/DSS Model in the Study of Colorectal Carcinogenesis ; Histogenesis of Colon Cancer in AOM/DSS Model -- from the Emergence of Precancerous Lesions to Late Carcinomas |
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Molecular Events Associated with Colon Carcinogenesis in the AOM/DSS Model and Relevance for Human CRC Wnt/APC/Ý-Catenin Pathway ; K-Ras ; c-Myc ; TGF-Ý ; Cox-2 ; iNOS ; p53 Pathway ; Epigenetic Modifications ; Pathogenesis and Molecular Biology of Colitis-Induced Carcinogenesis in the AOM/DSS Model; Proinflammatory Factors ; Regulatory Factors ; Chemokines ; Toll Like Receptors ; TIR8 ; Heparanase ; Oxidative Stress and DNA Damage; The AOM/DSS Model in Preclinical Studies ; Natural Plant Compounds ; Modulation of Physiological Molecules ; Synthetic Drugs ; Conclusion ; Acknowledgment |
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3.3. Mechanical Injury Induced Neointimal Hyperplasia 4. Animal Models of Structural Heart Disease ; 4.1. Ischemic Mitral Regurgitation ; Conclusion ; Acknowledgment ; References ; Canine Breast Cancer and Lymphoma as Modelsin Cancer Research ; Abstract ; 1. Introduction ; 1.1. Dogs as Appropriate Animal Models of Human Cancers ; 2. Canine Mammary Tumor Model ; 2.1. Expression Defects of Cell Cycle Regulators in the CMT Model ; Deregulation of p16/INK4A/ARF/INK4B Locus in CMTs ; 2.2. Genome-Wide Comparative Analysis of the Role of Critical Genes Involved in Human and Canine Mammary Tumors |
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2.3. Expression of miRNAs in Human Breast Cancer and the CMT Model 3. Canine Lymphoma Model ; Conclusion ; References ; Development of Cell Therapeutic Strategies for Alzheimer's Disease Using Animal Models ; Abstract ; Introduction ; Amyloid Cascade Hypothesis ; Transgenic Mice Models of AD ; Therapeutic Strategies Using Transgenic Mice Models of AD ; Microglia in the AD Brain ; Cell Therapeutic Strategies for AD ; Conclusion ; Acknowledgments ; References ; Animal Models for AntineoplasticChemotherapy-Induced Alopecia; Abstract ; Introduction ; The Biology of the Hair Follicles (HFs) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Carcinogenesis -- Animal models.
|
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Diseases -- Animal models.
|
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Animal models in research -- Moral and ethical aspects
|
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Research.
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Carcinogenesis.
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Disease Models, Animal
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Research
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Ethics
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Carcinogenesis
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research (function)
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MEDICAL -- Research.
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Research
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Carcinogenesis -- Animal models
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Diseases -- Animal models
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| Form |
Electronic book
|
| Author |
Murray, Sean A., editor
|
| LC no. |
2020687970 |
| ISBN |
9781624175886 |
|
1624175880 |
|
