Limit search to available items
Book Cover

Title Turning up the heat on pain : TRPV1 receptors in pain and inflammation / Annika B. Malmberg, Keith R. Bley, editors
Published Basel ; Boston : Birkhauser Verlag, ©2005


Description 1 online resource (xii, 249 pages) : illustrations
Series Progress in inflammation research
PIR (Series)
Contents Part I: Historical perspective on capsaicin and its receptor. Hot peppers, pain and analgesics / János Szolcsányi -- Part II: Molecular and cellular properties of vanilloid receptors. Structural determinants of TRPV1 functionality / Makoto Tominaga ; TRPV1 distribution and regulation / Janet Winter -- Part III: Pharmacology and physiology of vanilloid receptors. Insights into TRPV1 pharmacology provided by non-capsaicin ligands / Peter M. Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, Vladimir Pavlyukovets and Larry V. Pearce ; Endocannabinoids and vanilloid TRPV1 receptors / Ruth A. Ross ; Vanilloid receptor-mediated hyperalgesia and desensitization / Zoltán Sándor and Arpad Szallasi ; Capsaicin in human experimental pain models of skin, muscle and visceral sensitization / Lars Arendt-Nielsen and Ole K. Andersen -- Part IV: Vanilloid receptor involvement in disease states. TRPV1 in gut function, abdominal pain and functional bowel disorders / Peter Holzer ; TRPV1 in the airways / Maria G. Belvisi and Peter J. Barnes -- Part V: Therapeutic potential of vanilloid agonists and antagonists. TRPV1 agonist-based therapies: mechanism of action and clinical prospects / Keith R. Bley and Annika B. Malmberg ; TRPV1 agonist therapies in bladder diseases / Francisco Cruz, Carlos Silva and Paulo Dinis ; TRPV1 antagonists and chronic pain / Kenneth J. Valenzano, James D. Pomonis and Katharine Walker
Summary Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor ma
Bibliography Includes bibliographical references and index
In Springer e-books
Subject Nociceptors.
Inflammation -- Mediators.
Receptors, Drug -- antagonists & inhibitors
Receptors, Drug -- physiology
Inflammation Mediators
Capsaicin -- analogs & derivatives
Capsaicin -- pharmacology
Inflammation -- drug therapy
Pain -- drug therapy
MEDICAL -- Neuroscience.
PSYCHOLOGY -- Neuropsychology.
Inflammation -- Mediators.
Inflammation -- Mediators
Nozizeptor -- Schmerz -- Entzündung.
Schmerz -- Nozizeptor -- Entzündung.
Entzündung -- Schmerz -- Nozizeptor.
Form Electronic book
Author Malmberg, Annika B., 1966-
Bley, Keith R.
ISBN 3764370807