Limit search to available items
Book Cover
E-book

Title Molecular targeted radiosensitizers : opportunities and challenges / Henning Willers, Iris Eke, editors
Published Cham, Switzerland : Humana Press, 2020

Copies

Description 1 online resource
Series Cancer Drug Discovery and Development Ser
Cancer Drug Discovery and Development Ser
Contents Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges -- Translating Targeted Radiosensitizers into the Clinic -- Cartography of the Radiogenome of Human Cancers -- Mechanisms and Markers of Clinical Radioresistance -- Preclinical Strategies for Testing of Targeted Radiosensitizers -- 3D Radiation Biology for Identifying Radiosensitizers -- Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments -- Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers -- Targeting the DNA Damage Response for Radiosensitization -- Targeting Tumor Metabolism to Overcome Radioresistance.-Targeting Tumor Hypoxia -- Normalizing the Tumor Microenvironment for Radiosensitization -- Radiosensitizers in the Era of Immuno-Oncology -- Index
Summary Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology
Notes Includes index
Bibliography Includes bibliographical references and index
Subject Cancer -- Radiotherapy -- Molecular aspects
Radiation-sensitizing agents.
Neoplasms -- radiotherapy
Radiation-Sensitizing Agents
Radiation-Sensitizing Agents -- therapeutic use
Molecular Targeted Therapy
Radiotherapy.
Pharmacology.
Oncology.
Medical -- Radiology & Nuclear Medicine.
Medical -- Pharmacology.
Medical -- Oncology.
Radiation-sensitizing agents
Form Electronic book
Author Willers, Henning
Eke, Iris
ISBN 9783030497019
3030497011