Title CD4+CD25+ regulatory T cells : origin, function, and therapeutic potential / B. Kyewski and E. Suri-Payer (eds.)

Published Berlin ; New York : Springer, 2005

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Description 1 online resource (x, 330 pages) : illustrations Series Current topics in microbiology and immunology, 0070-217X ; 293 Current topics in microbiology and immunology ; 293. 0070-217X Contents Origin and Generation -- Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides -- The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology -- Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection -- Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models -- Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets -- Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells -- Dendritic Cells: Key Cells for the Induction of Regulatory T Cells? -- Involvement of Disease Models -- Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression -- Regulatory T Cells in Experimental Colitis -- Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control -- Regulatory T Cells in Transplantation Tolerance -- CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation -- Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity -- Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells Summary The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival Bibliography Includes bibliographical references In Springer e-books Subject T cells. T cells -- Receptors. CD4 antigen. CD25 antigen CD4-Positive T-Lymphocytes -- physiology CD4 Antigens Autoimmune Diseases -- immunology Receptors, Immunologic -- physiology Receptors, Interleukin-2 -- immunology Self Tolerance -- immunology MEDICAL -- Immunology. T cells -- Receptors. CD4 antigen. CD25 antigen. CD4-Positive T-Lymphocytes -- physiology. Autoimmune Diseases -- immunology. Receptors, Immunologic -- physiology. Receptors, Interleukin-2 -- immunology. Self Tolerance -- immunology. T cells. Biomédecine. Sciences de la vie. CD4 antigen T cells T cells -- Receptors Form Electronic book Author Kyewski, B. (Bruno) Suri-Payer, E. (Elisabeth) ISBN 3540244441 9783540244448 3540277021 9783540277026 1280412933 9781280412936 9786610412938 6610412936

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