| Description |
1 online resource : color illustrations |
| Series |
AAPS advances in the pharmaceutical sciences series, 2210-7371 ; 4 |
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AAPS advances in the pharmaceutical sciences series ; 4.
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| Contents |
880-01 Part 1. General Aspects -- Introduction to the Microdialysis Technology / Markus Müller -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis / Elizabeth C.M. de Lange -- Analytical Considerations for Microdialysis Sampling / Justin C. Cooley, Michael W. Ducey, Anne R. Regel, Pradyot Nandi and Susan M. Lunte, et al. -- Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective / Chinmay Shukla, Jing Li, Robert Lionberger and Edward D. Bashaw |
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880-01/(S Introduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques -- Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis-- Microdialysis in Internal Organs and Tumors |
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Part 2. Specific topics -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations / Margareta Hammarlund-Udenaes -- Microdialysis in Antibiotic Research / Markus Zeitlinger, Sandrine Marchand, William Couet, Aline Barth and Hartmut Derendorf -- Skin and Transdermal Drug Delivery / Advantages and Challenges / Eva Benfeldt -- Translational Approaches for Predicting CNS Drug Effects Using Microdialysis / Elizabeth de Lange -- Extracellular Amyloid-[beta] Protein Dynamics in Alzheimer's Disease / John R. Cirrito -- Microdialysis in Pain Research / Martin Brunner -- Microdialysis in Ocular Drug Development / Mitesh R. Patel, Nanda K. Mandava and Ashim K. Mitra -- Microdialysis in Metabolic Research / Per-Anders Jansson -- High Molecular Weight Targets and Treatments Using Microdialysis / Geraldine F. Clough, Julie A. Stenken and Martin K. Church -- Complementary Techniques: Positron Emission Tomography / Oliver Langer -- Open Flow Microperfusion: An Alternative Method to Microdialysis? / Thomas Pieber, Thomas Birngruber, Manfred Bodenlenz, Christian Höfferer and Selma Mautner, et al. -- Microdialysis in Internal Organs and Tumors / Robert Sauermann and Markus Zeitlinger |
| Summary |
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development |
| Analysis |
Medicine |
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Pharmaceutical technology |
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Biomedicine |
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Pharmaceutical Sciences/Technology |
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Biomedicine general |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| Subject |
Drug development.
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Dialysis.
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Drugs -- Bioavailability.
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Bioavailability.
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Brain microdialysis.
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Drugs.
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Biological Availability
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Microdialysis
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Pharmaceutical Preparations
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Dialysis
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MEDICAL -- Drug Guides.
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MEDICAL -- Nursing -- Pharmacology.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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Drugs
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Brain microdialysis
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Bioavailability
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Dialysis
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Drug development
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Drugs -- Bioavailability
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| Form |
Electronic book
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| Author |
Müller, Markus, 1967 August 23-
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| ISBN |
9781461448150 |
|
1461448158 |
|
146144814X |
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9781461448143 |
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