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E-book

Title Microdialysis in drug development / Markus Müller, editor
Published New York, NY : Springer, ©2013

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Description 1 online resource : color illustrations
Series AAPS advances in the pharmaceutical sciences series, 2210-7371 ; 4
AAPS advances in the pharmaceutical sciences series ; 4.
Contents 880-01 Part 1. General Aspects -- Introduction to the Microdialysis Technology / Markus Müller -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis / Elizabeth C.M. de Lange -- Analytical Considerations for Microdialysis Sampling / Justin C. Cooley, Michael W. Ducey, Anne R. Regel, Pradyot Nandi and Susan M. Lunte, et al. -- Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective / Chinmay Shukla, Jing Li, Robert Lionberger and Edward D. Bashaw
880-01/(S Introduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques -- Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis-- Microdialysis in Internal Organs and Tumors
Part 2. Specific topics -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations / Margareta Hammarlund-Udenaes -- Microdialysis in Antibiotic Research / Markus Zeitlinger, Sandrine Marchand, William Couet, Aline Barth and Hartmut Derendorf -- Skin and Transdermal Drug Delivery / Advantages and Challenges / Eva Benfeldt -- Translational Approaches for Predicting CNS Drug Effects Using Microdialysis / Elizabeth de Lange -- Extracellular Amyloid-[beta] Protein Dynamics in Alzheimer's Disease / John R. Cirrito -- Microdialysis in Pain Research / Martin Brunner -- Microdialysis in Ocular Drug Development / Mitesh R. Patel, Nanda K. Mandava and Ashim K. Mitra -- Microdialysis in Metabolic Research / Per-Anders Jansson -- High Molecular Weight Targets and Treatments Using Microdialysis / Geraldine F. Clough, Julie A. Stenken and Martin K. Church -- Complementary Techniques: Positron Emission Tomography / Oliver Langer -- Open Flow Microperfusion: An Alternative Method to Microdialysis? / Thomas Pieber, Thomas Birngruber, Manfred Bodenlenz, Christian Höfferer and Selma Mautner, et al. -- Microdialysis in Internal Organs and Tumors / Robert Sauermann and Markus Zeitlinger
Summary In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development
Analysis Medicine
Pharmaceutical technology
Biomedicine
Pharmaceutical Sciences/Technology
Biomedicine general
Bibliography Includes bibliographical references and index
Notes English
Subject Drug development.
Dialysis.
Drugs -- Bioavailability.
Bioavailability.
Brain microdialysis.
Drugs.
Biological Availability
Microdialysis
Pharmaceutical Preparations
Dialysis
MEDICAL -- Drug Guides.
MEDICAL -- Nursing -- Pharmacology.
MEDICAL -- Pharmacology.
MEDICAL -- Pharmacy.
Dialysis.
Drug development.
Drugs -- Bioavailability.
Form Electronic book
Author Müller, Markus, 1967 August 23-
ISBN 9781461448150
1461448158
146144814X
9781461448143