| Description |
1 online resource (xiii, 408 pages) : illustrations, photographs, many in color |
| Series |
Springer series in translational stroke research |
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Springer series in translational stroke research.
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| Contents |
Part I. Microvascular integrity in stroke ; Structural alterations to the endothelial tight junction complex during stroke / Anuska V. Andjelkovic and Richard F. Keep -- Role of pericytes in neurovascular unit and stroke / Turgay Dalkara, Luis Alarcon-Martinez, and Muge Yemisci -- Glial support of blood-brain barrier integrity : molecular targets for novel therapeutic strategies in stroke / Patrick T. Ronaldson and Thomas P. Davis -- Barrier mechanisms in neonatal stroke / Zinaida S. Vexler -- Angiogenesis : a realistic therapy for ischemic stroke / Ke-Jie Yin and Xinxin Yang |
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Part II. Glial cells in stroke ; Astrocytes as a target for ischemic stroke / Shinghua Ding -- Microglia : a double-sided sword in stroke / Hong Shi, Mingyue Xu, Yejie Shi, Yanqin Gao, Jun Chen, and Xiaoming Hu -- Crosstalk between cerebral endothelium and oligodendrocyte after stroke / Akihiro Shindo, Takakuni Maki, Kanako Itoh, Nobukazu Miyamoto, Naohiro Egawa, Anna C. Liang, Takayuki Noro, Josephine Lok, Eng H. Lo, and Ken Arai |
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Part III. Peripheral immune cells in stroke ; The peripheral immune response to stroke / Josef Anrather -- The role of spleen-derived immune cells in ischemic brain injury / Heng Zhao -- Regulatory T cells in ischemic brain injury / Arthur Liesz -- B-cells in stroke and preconditioning-induced protection against stroke / Uma Maheswari Selvaraj, Katie Poinsatte, and Ann M. Stowe -- Mast cell as an early responder in ischemic brain injury / Perttu J. Lindsberg, Olli S. Mattila, and Daniel Strbian -- Roles of neutrophils in stroke / Glen C. Jickling and Frank R. Sharp -- The function of cytokines in ischemic stroke / Christopher C. Leonardo and Keith R. Pennypacker |
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Part IV. White matter injury and repair in stroke ; Ischemic injury to white matter : an age-dependent process / Sylvain Brunet, Chinthasagar Bastian, and Selva Baltan |
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Part V. Emerging therapies to target non-neuronal mechanisms after stroke ; Neurovascular repair after stroke / Sherrefa R. Burchell, Wing-Mann Ho, Jiping Tang, and John H. Zhang -- The role of nonneuronal Nrf2 pathway in ischemic stroke : damage control and potential tissue repair / Tuo Yang, Yang Sun, and Feng Zhang -- Stem cell therapy for ischemic stroke / Hung Nguyen, Naoki Tajiri, and Cesar V. Borlongan |
| Summary |
This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials |
| Bibliography |
Includes bibliographical references at chapter ends |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed August 23, 2016) |
| Subject |
Cerebrovascular disease -- Molecular aspects
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Brain damage -- Molecular aspects
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Cerebral ischemia.
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Brain Ischemia
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cerebral ischemia
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| Author |
Chen, Jun (Professor of neurology and pharmacology), editor, author.
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Hu, Xiaoming, active 2014, editor, author.
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Zhang, J. H. (John H.), editor, author.
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| ISBN |
9783319323374 |
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3319323377 |
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