Title Bioactive natural products in drug discovery / Joginder Singh, Vineet Meshram, Mahiti Gupta, editors

Published Singapore : Springer, 2020

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Description 1 online resource Contents Intro -- Preface -- Contents -- About the Editors -- Part I: Plants Natural Products: Fountainheads for Drug Discovery and Development -- 1: The Artemisia Genus: Panacea to Several Maladies -- 1.1 Introduction -- 1.2 Phytochemistry -- 1.3 Conservation of Artemisia Species -- 1.4 Conclusions -- References -- 2: Bacopa monnieri: The Neuroprotective Elixir from the East-Phytochemistry, Pharmacology, and Biotechnological Improvement -- 2.1 Introduction -- 2.2 Methodology -- 2.3 Bioactivity Study -- 2.3.1 Biological Activities of Plant Extract(s) -- 2.3.1.1 Pro-cognitive Activity 2.3.1.2 Anti-neurodegenerative Activity -- 2.3.1.3 Antidepressant and Anti-stress Activity -- 2.3.1.4 Neuroprotective Activity -- 2.3.1.5 Cardioprotection -- 2.3.1.6 Gastrointestinal and Hepatoprotective Activity -- 2.3.1.7 Antiemetic Activity -- 2.3.1.8 Anti-epileptic Activity -- 2.3.1.9 Antioxidant Activity -- 2.3.1.10 Miscellaneous Activity -- 2.3.2 Pharmacological Activity of the Active Compounds -- 2.3.2.1 Bacoside A -- Anti-Alzheimerś Activity -- Anti-apoptotic Activity -- Anti-epileptic Activity -- Antidepressant Activity -- Anti-dopaminergic Activity -- Anti-inflammatory Activity Antioxidant Activity -- Hepatoprotection -- Neuroprotection -- Protease Inhibition Activity -- Renoprotective Activity -- Wound-Healing Activity -- 2.3.2.2 Bacopaside I -- 2.3.2.3 Betulinic Acid -- 2.3.3 Pharmacological Activity of the Polyherbal Formulation(S) -- 2.3.3.1 Cognition -- 2.3.3.2 Hepatic Encephalopathy -- 2.4 Biotechnological Advancement -- 2.5 Toxicity Study -- 2.6 Drug Designing -- 2.7 Structure-Activity Relationship -- 2.8 Summary -- 2.9 Conclusion -- References 3: Current Knowledge of Cinnamomum Species: A Review on the Bioactive Components, Pharmacological Properties, Analytical and B ... -- 3.1 Introduction -- 3.2 Botanical Description -- 3.3 Distribution -- 3.4 Traditional Use and Polyherbal Formulation of Cinnamon -- 3.5 Pharmacological Property of Cinnamomum Species -- 3.5.1 Anti-inflammatory Activity -- 3.5.2 Antibacterial Activity -- 3.5.3 Antifungal Activity -- 3.5.4 Antiviral Activity -- 3.5.5 Antioxidant Activity -- 3.5.6 Anticancer Activity -- 3.5.7 Gastroprotective Activity -- 3.5.8 Hypoglycemic/Anti-lipidemic Activity 3.5.9 Immunomodulatory Properties -- 3.5.10 Neuroprotective Activity -- 3.5.11 Cardioprotective Activity -- 3.6 Phytochemistry of Cinnamon -- 3.7 Clinical Study Based on Cinnamon -- 3.8 Extraction and Isolation of Bioactive Phytochemicals -- 3.9 Biotechnological Techniques for Large-Scale Multiplication of Cinnamomum Species -- 3.10 Molecular Markers for Genetic Diversity Assessment of Cinnamomum Species -- 3.11 Discussion and Conclusion -- References -- 4: Swertia spp.: A Potential Source of High-Value Bioactive Components, Pharmacology, and Analytical Techniques -- 4.1 Introduction Summary This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the books closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the books goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies Notes Includes index Subject Drug development. Natural products. Pharmaceutical chemistry. Pharmacognosy. Materia medica, Vegetable. Medicine, Botanic. Drug Discovery Phytotherapy Pharmacognosy Chemistry, Pharmaceutical Pharmacognosy Medicine, Botanic Materia medica, Vegetable Drug development Natural products Pharmaceutical chemistry Botànica mèdica. Genètica vegetal. Farmacologia. Genre/Form e-books. Livres numériques. Llibres electrònics. Form Electronic book Author Singh, Joginder Meshram, Vineet Gupta, Mahiti ISBN 9789811513947 9811513945 9789811513954 9811513953 9789811513961 9811513961

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